Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24309708 | 0.83 | MAPT (0.44) | MAPTTSHRSMN1; SMN2MEN1KMT2A | |
| SCHEMBL26807008 | 0.76 | MAPT (0.47) | MAPTTSHRSMN1; SMN2MEN1KMT2A | |
| SCHEMBL26806813 | 0.75 | MAPT (0.61) | MAPTTSHRSMN1; SMN2MEN1KMT2A | |
| SCHEMBL26810968 | 0.74 | MAPT (0.44) | MAPTTSHRSMN1; SMN2MEN1KMT2A | |
| SCHEMBL26806984 | 0.73 | MAPT (0.55) | MAPTTSHRSMN1; SMN2MEN1KMT2A | |
| SCHEMBL26806972 | 0.73 | TSHR (0.57) | MAPTTSHRSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL24310288 | 0.73 | TSHR (0.57) | MAPTTSHRSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL29567077 | 0.73 | TSHR (0.57) | MAPTTSHRSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL26806947 | 0.73 | MAPT (0.55) | MAPTTSHRSMN1; SMN2MEN1KMT2A | |
| SCHEMBL24309689 | 0.73 | MAPT (0.47) | MAPTTSHRSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225748-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |