Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 8/20 | 0.37 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ROS1 | P08922 | 1/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24309391 | 1.00 | RAD52 (0.37) | RAD52BRD4MAP4K1PDE2APDE10A | |
| SCHEMBL29566568 | 0.93 | HTR2C (0.39) | RAD52BRD4HTR2CHTR6JAK2 | |
| SCHEMBL24310685 | 0.93 | HTR2C (0.39) | RAD52BRD4HTR2CHTR6JAK2 | |
| SCHEMBL26808704 | 0.92 | RAD52 (0.39) | RAD52BRD4MAP4K1PDE2APDE10A | |
| SCHEMBL29567333 | 0.90 | RAD52 (0.39) | RAD52BRD4MAP4K1PDE2APDE10A | |
| SCHEMBL24309887 | 0.90 | RAD52 (0.39) | RAD52BRD4MAP4K1PDE2APDE10A | |
| SCHEMBL24309717 | 0.89 | RAD52 (0.39) | RAD52BRD4MAP4K1PDE2APDE10A | |
| SCHEMBL29567239 | 0.89 | RAD52 (0.39) | RAD52BRD4MAP4K1PDE2APDE10A | |
| SCHEMBL24310422 | 0.88 | PDE2A (0.40) | RAD52BRD4MAP4K1PDE2APDE10A | |
| SCHEMBL29567000 | 0.88 | PDE2A (0.40) | RAD52BRD4MAP4K1PDE2APDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225748-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |