Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 1/20 | 0.67 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.67 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.67 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.35 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.35 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.35 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.35 |
| ▸ | F12 | P00748 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.34 |
| ▸ | BACE1 | P56817 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1941881 | 1.00 | PDGFRA (0.67) | PDGFRACDK5TYRO3MAP2K4USP30 | |
| SCHEMBL29439761 | 0.90 | PDGFRA (0.52) | PDGFRACDK5TYRO3MAP2K4USP30 | |
| SCHEMBL1943689 | 0.90 | PDGFRA (0.52) | PDGFRACDK5TYRO3MAP2K4USP30 | |
| SCHEMBL13737806 | 0.85 | PDGFRA (0.47) | PDGFRACDK5TYRO3MAP2K4SMARCA2 | |
| SCHEMBL11232 | 0.85 | PDGFRA (0.47) | PDGFRACDK5TYRO3MAP2K4USP30 | |
| SCHEMBL18764614 | 0.84 | PDGFRA (0.46) | PDGFRACDK5TYRO3MAP2K4USP30 | |
| SCHEMBL16355545 | 0.84 | PDGFRA (0.59) | PDGFRACDK5TYRO3USP30AAK1 | |
| SCHEMBL11750740 | 0.84 | PDGFRA (0.46) | PDGFRACDK5TYRO3MAP2K4SMARCA2 | |
| SCHEMBL6480204 | 0.84 | PDGFRA (0.46) | PDGFRACDK5TYRO3MAP2K4SMARCA2 | |
| SCHEMBL31182074 | 0.83 | PDGFRA (0.45) | PDGFRACDK5TYRO3MAP2K4USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3956315-A1 | BENZO- AND PYRIDO-PYRAZOLES AS PROTEIN KINASE INHIBITORS | Rottapharm Biotech S.r.l. (IT) | 2022-02-23 | — | — | EP | disclosed |