Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29570205 | 0.86 | MAPT (0.46) | MAPTSMN1; SMN2KMT2AMEN1CYP1A2 | |
| SCHEMBL30676295 | 0.83 | CYP26A1 (0.45) | MAPTSMN1; SMN2KMT2AMEN1LMNA | |
| SCHEMBL30676245 | 0.83 | CYP26A1 (0.45) | MAPTSMN1; SMN2KMT2AMEN1LMNA | |
| SCHEMBL29571174 | 0.83 | CYP26A1 (0.45) | MAPTSMN1; SMN2KMT2AMEN1LMNA | |
| SCHEMBL30676243 | 0.83 | CYP26A1 (0.45) | MAPTSMN1; SMN2KMT2AMEN1LMNA | |
| SCHEMBL29570171 | 0.83 | CYP26A1 (0.45) | MAPTSMN1; SMN2KMT2AMEN1LMNA | |
| SCHEMBL9070698 | 0.80 | MAPT (0.43) | MAPTSMN1; SMN2KMT2AMEN1CYP1A2 | |
| SCHEMBL23377838 | 0.76 | MAPT (0.45) | MAPTSMN1; SMN2KMT2AMEN1CYP1A2 | |
| SCHEMBL23377841 | 0.76 | MAPT (0.45) | MAPTSMN1; SMN2KMT2AMEN1CYP1A2 | |
| SCHEMBL24370406 | 0.76 | KCNN4 (0.44) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4229056-A1 | TRIAZOLOPYRIDINYL COMPOUNDS AS KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022086828-A1 | TRIAZOLOPYRIDINYL COMPOUNDS AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2022-04-28 | — | — | WO | disclosed |