Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.36 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | FNTA | P49354 | 1/20 | 0.33 |
| ▸ | FNTB | P49356 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL295723 | 1.00 | SMN1; SMN2 (0.40) | SMN1; SMN2NPC1S1PR1S1PR2S1PR3 | |
| Hydrochloric Acid SCHEMBL296349 | 0.99 | SMN1; SMN2 (0.39) | SMN1; SMN2NPC1S1PR1S1PR2S1PR3 | |
| Hydrochloric Acid SCHEMBL296348 | 0.99 | SMN1; SMN2 (0.39) | SMN1; SMN2NPC1S1PR1S1PR2S1PR3 | |
| SCHEMBL13385093 | 0.89 | SMN1; SMN2 (0.41) | SMN1; SMN2NPC1S1PR1S1PR2S1PR3 | |
| SCHEMBL295020 | 0.87 | S1PR1 (0.48) | SMN1; SMN2NPC1S1PR1S1PR2S1PR3 | |
| SCHEMBL295021 | 0.87 | S1PR1 (0.48) | SMN1; SMN2NPC1S1PR1S1PR2S1PR3 | |
| SCHEMBL296270 | 0.85 | S1PR1 (0.46) | S1PR1S1PR2S1PR3LPAR2NR1H2 | |
| SCHEMBL296295 | 0.79 | SMN1; SMN2 (0.44) | SMN1; SMN2NPC1S1PR1S1PR3POLB | |
| SCHEMBL293675 | 0.79 | SMN1; SMN2 (0.41) | SMN1; SMN2S1PR1S1PR3ALDH1A1NPSR1 | |
| SCHEMBL293676 | 0.79 | SMN1; SMN2 (0.41) | SMN1; SMN2S1PR1S1PR3ALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636171-B1 | AMINO-PROPANOL DERIVATIVES AS SPHINGOSINE-1-PHOSPHATE RECEPTOR MODULATORS | NOVARTIS AG (CH) | 2012-03-14 | — | — | EP | claimed |
| EP-1636171-B1 | AMINO-PROPANOL DERIVATIVES AS SPHINGOSINE-1-PHOSPHATE RECEPTOR MODULATORS | NOVARTIS AG (CH) | 2012-03-14 | — | — | EP | disclosed |