Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.92 |
| ▸ | KDR | P35968 | 4/20 | 0.84 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.84 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.84 |
| ▸ | BRAF | P15056 | 2/20 | 0.84 |
| ▸ | FLT4 | P35916 | 2/20 | 0.84 |
| ▸ | CIT | O14578 | 2/20 | 0.84 |
| ▸ | GAK | O14976 | 2/20 | 0.84 |
| ▸ | EPHB6 | O15197 | 2/20 | 0.84 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.84 |
| ▸ | STK17B | O94768 | 2/20 | 0.84 |
| ▸ | STK10 | O94804 | 2/20 | 0.84 |
| ▸ | ABL1 | P00519 | 2/20 | 0.84 |
| ▸ | LCK | P06239 | 2/20 | 0.84 |
| ▸ | LYN | P07948 | 2/20 | 0.84 |
| ▸ | RET | P07949 | 2/20 | 0.84 |
| ▸ | MET | P08581 | 2/20 | 0.84 |
| ▸ | HCK | P08631 | 2/20 | 0.84 |
| ▸ | FGR | P09769 | 2/20 | 0.84 |
| ▸ | KIT | P10721 | 2/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28935220 | 1.00 | EGFR (0.92) | EGFRKDREPHB4ERBB2BRAF | |
| SCHEMBL11019 | 0.96 | EGFR (1.00) | EGFRKDREPHB4ERBB2BRAF | |
| SCHEMBL29577833 | 0.95 | EGFR (0.92) | EGFRKDREPHB4ERBB2BRAF | |
| SCHEMBL28713534 | 0.95 | EGFR (0.92) | EGFRKDREPHB4ERBB2BRAF | |
| SCHEMBL31491114 | 0.93 | EGFR (0.87) | EGFRKDREPHB4ERBB2BRAF | |
| SCHEMBL1446333 | 0.93 | EGFR (0.79) | EGFRKDREPHB4ERBB2BRAF | |
| SCHEMBL31491173 | 0.92 | EGFR (0.86) | EGFRKDREPHB4ERBB2BRAF | |
| SCHEMBL31491135 | 0.92 | EGFR (0.86) | EGFRKDREPHB4ERBB2BRAF | |
| SCHEMBL31491130 | 0.92 | EGFR (0.86) | EGFRKDREPHB4ERBB2BRAF | |
| SCHEMBL19612073 | 0.92 | EGFR (0.86) | EGFRKDREPHB4ERBB2BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108069913-B | Bis (morpholinylalkoxy) quinazoline derivative and application thereof in anti-tumor aspect | 陕西师范大学 | 2022-03-01 | — | — | CN | disclosed |