Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.93 |
| ▸ | ERBB2 | P04626 | 14/20 | 0.71 |
| ▸ | GAK | O14976 | 2/20 | 0.68 |
| ▸ | KDR | P35968 | 2/20 | 0.67 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.67 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.67 |
| ▸ | CIT | O14578 | 1/20 | 0.63 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.63 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.63 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.63 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.63 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.63 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.63 |
| ▸ | STK17B | O94768 | 1/20 | 0.63 |
| ▸ | STK10 | O94804 | 1/20 | 0.63 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.63 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.63 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.63 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.63 |
| ▸ | ABL1 | P00519 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28711991 | 1.00 | EGFR (0.93) | EGFRERBB2GAKKDREPHB4 | |
| SCHEMBL28704044 | 0.96 | EGFR (1.00) | EGFRERBB2GAKKDREPHB4 | |
| SCHEMBL29578131 | 0.96 | EGFR (1.00) | EGFRERBB2GAKKDREPHB4 | |
| SCHEMBL2510110 | 0.93 | EGFR (0.93) | EGFRERBB2GAKKDREPHB4 | |
| SCHEMBL31193415 | 0.91 | EGFR (0.77) | EGFRERBB2 | |
| SCHEMBL2247234 | 0.90 | EGFR (0.89) | EGFRERBB2GAKKDREPHB4 | |
| SCHEMBL12743359 | 0.90 | EGFR (0.88) | EGFRERBB2GAKKDREPHB4 | |
| SCHEMBL4028923 | 0.89 | EGFR (0.74) | EGFRERBB2 | |
| SCHEMBL23450866 | 0.88 | EGFR (0.76) | EGFRERBB2GAKKDREPHB4 | |
| SCHEMBL2252507 | 0.87 | EGFR (0.83) | EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108069913-B | Bis (morpholinylalkoxy) quinazoline derivative and application thereof in anti-tumor aspect | 陕西师范大学 | 2022-03-01 | — | — | CN | disclosed |