Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 14/20 | 0.70 |
| ▸ | FGFR4 | P22455 | 13/20 | 0.64 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.64 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | CSF1R | P07333 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20331607 | 1.00 | FGFR1 (0.70) | FGFR1FGFR4FGFR2FGFR3CYP1A2 | |
| SCHEMBL21320815 | 0.94 | FGFR1 (0.70) | FGFR1FGFR4FGFR2FGFR3CYP1A2 | |
| SCHEMBL20331628 | 0.94 | FGFR1 (0.69) | FGFR1FGFR4FGFR2FGFR3CYP1A2 | |
| SCHEMBL29578052 | 0.94 | FGFR1 (0.69) | FGFR1FGFR4FGFR2FGFR3CYP1A2 | |
| SCHEMBL29577513 | 0.93 | FGFR1 (0.72) | FGFR1FGFR4FGFR2FGFR3CYP1A2 | |
| SCHEMBL20331911 | 0.93 | FGFR1 (0.72) | FGFR1FGFR4FGFR2FGFR3CYP1A2 | |
| SCHEMBL20331619 | 0.93 | FGFR1 (0.66) | FGFR1FGFR4FGFR2FGFR3CYP1A2 | |
| SCHEMBL30045185 | 0.93 | FGFR1 (0.66) | FGFR1FGFR4FGFR2FGFR3CYP1A2 | |
| SCHEMBL30045330 | 0.92 | FGFR1 (0.68) | FGFR1FGFR4FGFR2FGFR3CYP1A2 | |
| SCHEMBL20331999 | 0.92 | FGFR1 (0.68) | FGFR1FGFR4FGFR2FGFR3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3524603-B1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | ABBISKO THERAPEUTICS CO LTD (CN) | 2022-06-08 | — | — | EP | disclosed |