Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 13/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 7/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.38 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.37 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20331836 | 1.00 | FGFR4 (0.43) | FGFR4FGFR1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL20331833 | 0.91 | FGFR4 (0.46) | FGFR4FGFR1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL29578132 | 0.91 | FGFR4 (0.46) | FGFR4FGFR1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL30046215 | 0.88 | FGFR4 (0.46) | FGFR4FGFR1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL21240197 | 0.88 | FGFR4 (0.46) | FGFR4FGFR1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL29577638 | 0.86 | FGFR4 (0.44) | FGFR4FGFR1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL21240211 | 0.86 | FGFR4 (0.44) | FGFR4FGFR1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL20331532 | 0.86 | FGFR4 (0.54) | FGFR4FGFR1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL30045310 | 0.86 | FGFR4 (0.54) | FGFR4FGFR1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL21240125 | 0.82 | FGFR4 (0.59) | FGFR4FGFR1CYP2C9FGFR2CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3524603-B1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | ABBISKO THERAPEUTICS CO LTD (CN) | 2022-06-08 | — | — | EP | disclosed |