SCHEMBL2957985

SCHEMBL2957985

Nc1ncnc2c1c(-c1ccc3c(ccn3Cc3ccccc3Cl)c1)nn2C1CCC(N2CCC(CCO)CC2)CC1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ IGF1R P08069 12/20 0.53
▸ EGFR P00533 7/20 0.53
▸ ERBB2 P04626 3/20 0.53
▸ PIK3CD O00329 6/20 0.49
▸ PIK3CA P42336 5/20 0.49
▸ PIK3CB P42338 5/20 0.49
▸ PIK3CG P48736 5/20 0.49
▸ PRKDC P78527 5/20 0.49
▸ SRC P12931 5/20 0.49
▸ ABL1 P00519 4/20 0.49
▸ HCK P08631 4/20 0.49
▸ KDR P35968 4/20 0.49
▸ MTOR P42345 4/20 0.49
▸ EPHB4 P54760 4/20 0.49
▸ PI4KB Q9UBF8 2/20 0.47
▸ TGFBR1 P36897 1/20 0.45
▸ ERBB3 P21860 1/20 0.44
▸ ERBB4 Q15303 1/20 0.44
▸ LCK P06239 1/20 0.44
▸ TEK Q02763 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2966043 1.00 IGF1R (0.53) IGF1REGFRERBB2PIK3CDPIK3CA
SCHEMBL2967439 1.00 IGF1R (0.53) IGF1REGFRERBB2PIK3CDPIK3CA
SCHEMBL2959607 0.94 IGF1R (0.54) IGF1REGFRERBB2PIK3CDPIK3CA
SCHEMBL2956132 0.94 IGF1R (0.54) IGF1REGFRERBB2PIK3CDPIK3CA
SCHEMBL2956130 0.94 IGF1R (0.54) IGF1REGFRERBB2PIK3CDPIK3CA
SCHEMBL2960030 0.91 IGF1R (0.57) IGF1REGFRERBB2PIK3CDPIK3CA
SCHEMBL2956089 0.90 SRC (0.51) IGF1REGFRERBB2PIK3CDPIK3CA
SCHEMBL2956066 0.90 IGF1R (0.53) IGF1REGFRERBB2PIK3CDPIK3CA
SCHEMBL2956065 0.90 IGF1R (0.53) IGF1REGFRERBB2PIK3CDPIK3CA
SCHEMBL2958145 0.90 IGF1R (0.53) IGF1REGFRERBB2PIK3CDPIK3CA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 302 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111629694-B Fiber bundle reinforced biocomposite medical implant 奥西西奥有限公司 2024-05-17 — — CN claimed
CN-116963718-A Composition for ophthalmic care 瑞比奥科技公司 2023-10-27 — — CN claimed
CN-111050677-B Fiber reinforced biocomposite threaded implant 奥西西奥有限公司 2023-06-20 — — CN claimed
CN-106687077-B Anisotropic biocomposite, medical implant comprising anisotropic biocomposite, and method of treatment thereof 奥西奥有限公司 2021-07-27 — — CN claimed
CN-107106210-B Continuous fiber reinforced biocomposite medical implants 奥西奥有限公司 2021-05-04 — — CN claimed
CN-112601560-A Precision surface treated biocomposite, medical implant comprising same, and method of treating same 奥西西奥有限公司 2021-04-02 — — CN claimed
CN-111629694-A Fiber bundle reinforced biocomposite medical implant 奥西西奥有限公司 2020-09-04 — — CN claimed
EP-1753708-B1 NOVEL SIRTUIN ACTIVATING COMPOUNDS AND METHODS FOR MAKING THE SAME UNIV BRIGHAM YOUNG (US) 2018-02-21 — — EP claimed
EP-1973917-B1 PROTEIN KINASE INHIBITORS ABBVIE INC (US) 2015-06-10 — — EP claimed
US-7772231-B2 Substituted pyrazolo[3,4-d]pyrimidines as protein kinase inhibitors ABBOTT LABORATORIES (US) 2010-08-10 — — US claimed
EP-1753708-A4 NOVEL SIRTUIN ACTIVATING COMPOUNDS AND METHODS FOR MAKING THE SAME UNIV BRIGHAM YOUNG (US) 2007-12-26 — — EP claimed
EP-1753708-A2 NOVEL SIRTUIN ACTIVATING COMPOUNDS AND METHODS FOR MAKING THE SAME Brigham Young University (US) 2007-02-21 — — EP claimed
WO-2005069998-A2 NOVEL SIRTUIN ACTIVATING COMPOUNDS AND METHODS FOR MAKING THE SAME BRIGHAM YOUNG UNIVERSITY TECHNOLOGY TRANSFER OFFICE (US) 2005-08-04 — — WO claimed
EP-0733087-B1 CROSS-LINKING AGENTS FOR POLYMERS WITH ACID ANHYDRIDE GROUPS ATOCHEM ELF SA (FR) 2001-03-14 — — EP claimed
EP-0662106-B1 SINGLE-COMPONENT THERMOSETTING MASSES, STORAGE STABLE AT ROOM TEMPERATURE, MADE OF ANHYDRIDE GROUP-CONTAINING POLYMERS AND POWDERY CROSS-LINKING AGENTS, PROCESS FOR PRODUCING THE SAME AND THEIR USE CIBA GEIGY AG (CH) 1997-08-27 — — EP claimed
US-12042507-B2 Compositions and methods of modulating HIF-2A to improve muscle generation and repair UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) 2024-07-23 — — US disclosed
CN-118320091-A Compositions of caspase inhibitors and methods of use thereof 香港大学 2024-07-12 — — CN disclosed
US-4159387-A Squaric acid esters CIBA-GEIGY CORPORATION (US) 1979-06-26 — — US disclosed
US-4159387-A Squaric acid esters CIBA-GEIGY CORPORATION (US) 1979-06-26 — — US disclosed
US-4137221-A Heat-curable and solvent-soluble ester group-containing polymer compositions and process for their preparation TEIJIN LIMITED (JP) 1979-01-30 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12042507-B2 Compositions and methods of modulating HIF-2A to improve muscle generation and repair HIF1A, HIF1AN, MYLK2 IGF1R 1277/4885EGFR 4045/4885ERBB2 1681/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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