Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PROKR1 | Q8TCW9 | 3/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 12/20 | 0.39 |
| ▸ | BCHE | P06276 | 8/20 | 0.39 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.39 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17064700 | 1.00 | MEN1 (0.44) | MEN1NPC1TP53TSHRRAB9A | |
| SCHEMBL18631570 | 0.82 | PROKR1 (0.38) | MEN1NPC1TP53TSHRRAB9A | |
| SCHEMBL17065065 | 0.77 | MAPT (0.51) | KMT2AACHEBCHE | |
| SCHEMBL11662610 | 0.76 | JMJD6 (0.63) | PROKR1JMJD6HTR4 | |
| SCHEMBL362870 | 0.75 | UHRF1 (0.43) | MEN1NPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL11622768 | 0.75 | SMN1; SMN2 (0.41) | NPC1RAB9ASMN1; SMN2PROKR1 | |
| SCHEMBL29740179 | 0.74 | GSK3B (0.50) | PROKR1 | |
| SCHEMBL1884527 | 0.74 | GSK3B (0.50) | PROKR1 | |
| SCHEMBL12672263 | 0.74 | UHRF1 (0.42) | KMT2APROKR1 | |
| SCHEMBL29740180 | 0.74 | GSK3B (0.50) | PROKR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4663636-A2 | TRIFLUOROMETHYL SUBSTITUTED PYRAZOLES AS HUMAN PLASMA KALLIKREIN INHIBITORS | BioCryst Pharmaceuticals, Inc. (US) | 2025-12-17 | — | — | EP | disclosed |
| CN-114591212-B | Human plasma kallikrein inhibitors | 拜奥克里斯特制药公司 | 2025-01-28 | — | — | CN | disclosed |
| CN-113307772-B | Human plasma kallikrein inhibitors | 拜奥克里斯特制药公司 | 2024-06-28 | — | — | CN | disclosed |
| CN-114591212-A | Human plasma kallikrein inhibitors | 拜奥克里斯特制药公司 | 2022-06-07 | — | — | CN | disclosed |
| CN-108289893-B | Human plasma kallikrein inhibitors | 拜奥克里斯特制药公司 | 2022-04-12 | — | — | CN | disclosed |