Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 14/20 | 0.55 |
| ▸ | F10 | P00742 | 2/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28721772 | 1.00 | KLKB1 (0.55) | KLKB1F10HCRTR1HCRTR2OPRK1 | |
| SCHEMBL20446521 | 0.95 | KLKB1 (0.52) | KLKB1F10HCRTR1HCRTR2 | |
| SCHEMBL20446528 | 0.95 | KLKB1 (0.52) | KLKB1F10HCRTR1HCRTR2 | |
| SCHEMBL20446526 | 0.95 | KLKB1 (0.52) | KLKB1F10HCRTR1HCRTR2 | |
| SCHEMBL20584258 | 0.87 | KLKB1 (0.74) | KLKB1F10KCNH2 | |
| SCHEMBL29580848 | 0.87 | KLKB1 (0.74) | KLKB1F10KCNH2 | |
| SCHEMBL20446523 | 0.85 | KLKB1 (0.50) | KLKB1F10HCRTR1HCRTR2GAA | |
| SCHEMBL24570383 | 0.81 | KLKB1 (0.44) | KLKB1 | |
| SCHEMBL20584700 | 0.80 | KLKB1 (0.52) | KLKB1F10 | |
| SCHEMBL20584698 | 0.80 | KLKB1 (0.52) | KLKB1F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114591212-A | Human plasma kallikrein inhibitors | 拜奥克里斯特制药公司 | 2022-06-07 | — | — | CN | disclosed |
| CN-108289893-B | Human plasma kallikrein inhibitors | 拜奥克里斯特制药公司 | 2022-04-12 | — | — | CN | disclosed |