Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM5A | P29375 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29243487 | 1.00 | IGF1R (0.44) | IGF1RALKPKML3MBTL1MAPT | |
| SCHEMBL29243661 | 1.00 | IGF1R (0.44) | IGF1RALKPKML3MBTL1MAPT | |
| SCHEMBL29585156 | 1.00 | IGF1R (0.44) | IGF1RALKPKML3MBTL1MAPT | |
| SCHEMBL24424310 | 0.92 | KMT2A (0.47) | MAPTTP53THRBALDH1A1POLB | |
| SCHEMBL29583230 | 0.92 | KMT2A (0.47) | MAPTTP53THRBALDH1A1POLB | |
| SCHEMBL29585943 | 0.87 | POLB (0.44) | IGF1RALKPKML3MBTL1MAPT | |
| SCHEMBL29585102 | 0.87 | POLB (0.44) | IGF1RALKPKML3MBTL1MAPT | |
| SCHEMBL29585144 | 0.87 | POLB (0.45) | PKML3MBTL1MAPTALDH1A1POLB | |
| SCHEMBL25090687 | 0.86 | POLB (0.44) | IGF1RALKMAPTPOLBKMT2A | |
| SCHEMBL24422977 | 0.86 | POLB (0.44) | IGF1RALKMAPTPOLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4240736-A1 | PPAR GAMMA MODULATORS AND METHODS OF USE | Eisai R&D Management Co., Ltd. (JP) | 2023-09-13 | — | — | EP | disclosed |
| CN-116635380-A | PPARgamma modulators and methods of use | 卫材R&D管理有限公司 | 2023-08-22 | — | — | CN | disclosed |
| WO-2022099144-A1 | ΡΡΑRγ MODULATORS AND METHODS OF USE | Eisai R&D Mangement Co., Ltd. (JP) | 2022-05-12 | — | — | WO | disclosed |