Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 6/20 | 0.49 |
| ▸ | RAF1 | P04049 | 5/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | CCNC | P24863 | 2/20 | 0.41 |
| ▸ | CDK8 | P49336 | 2/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14783816 | 1.00 | BRAF (0.49) | BRAFRAF1MAPK14KDRFGFR1 | |
| SCHEMBL14783128 | 0.94 | BRAF (0.42) | BRAFRAF1MAPK14KDRFGFR1 | |
| SCHEMBL29591396 | 0.94 | BRAF (0.42) | BRAFRAF1MAPK14KDRFGFR1 | |
| SCHEMBL14783575 | 0.94 | AKT1 (0.46) | BRAFRAF1KDRFGFR1PIK3CA | |
| SCHEMBL29592527 | 0.94 | AKT1 (0.46) | BRAFRAF1KDRFGFR1PIK3CA | |
| SCHEMBL29590861 | 0.93 | MAPT (0.43) | BRAFKDRCCNCCDK8IKBKB | |
| SCHEMBL14783123 | 0.93 | MAPT (0.43) | BRAFKDRCCNCCDK8IKBKB | |
| SCHEMBL29590628 | 0.93 | BRAF (0.49) | BRAFRAF1MAPK14KDRFGFR1 | |
| SCHEMBL14783473 | 0.93 | BRAF (0.49) | BRAFRAF1MAPK14KDRFGFR1 | |
| SCHEMBL17416963 | 0.92 | BRAF (0.51) | BRAFRAF1MAPK14KDRFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115403531-A | Chemical entities, compositions, and methods as kinase inhibitors | 润新生物公司 | 2022-11-29 | — | — | CN | disclosed |
| CN-108794411-B | Certain chemical entities, compositions, and methods | 润新生物公司 | 2022-06-07 | — | — | CN | disclosed |