Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.78 |
| ▸ | MAPK8 | P45983 | 11/20 | 0.78 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.76 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.76 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.76 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.73 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.73 |
| ▸ | NLK | Q9UBE8 | 2/20 | 0.73 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.73 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.71 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.71 |
| ▸ | GAK | O14976 | 1/20 | 0.59 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.59 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.59 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.59 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.59 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.59 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5113603 | 1.00 | MAPK14 (0.78) | MAPK14MAPK8MAPK11MAPK9MAPK10 | |
| SCHEMBL5120939 | 1.00 | MAPK14 (0.78) | MAPK14MAPK8MAPK11MAPK9MAPK10 | |
| SCHEMBL29594231 | 1.00 | MAPK14 (0.78) | MAPK14MAPK8MAPK11MAPK9MAPK10 | |
| SCHEMBL29594238 | 1.00 | MAPK14 (0.78) | MAPK14MAPK8MAPK11MAPK9MAPK10 | |
| SCHEMBL5120288 | 1.00 | MAPK14 (0.78) | MAPK14MAPK8MAPK11MAPK9MAPK10 | |
| SCHEMBL13239778 | 0.91 | MAPK14 (0.84) | MAPK14MAPK8MAPK11MAPK9MAPK10 | |
| SCHEMBL13239775 | 0.91 | MAPK14 (0.84) | MAPK14MAPK8MAPK11MAPK9MAPK10 | |
| SCHEMBL20875281 | 0.90 | MAPK14 (0.79) | MAPK14MAPK8MAPK11MAPK9MAPK10 | |
| SCHEMBL5121153 | 0.90 | MAPK14 (0.79) | MAPK14MAPK8MAPK11MAPK9MAPK10 | |
| SCHEMBL14014949 | 0.90 | MAPK14 (0.79) | MAPK14MAPK8MAPK11MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114748622-B | P38 kinase inhibitors reduce DUX4 and downstream gene expression and treat FSHD | 弗尔康医疗公司 | 2024-09-24 | — | — | CN | disclosed |
| CN-114732910-B | P38 kinase inhibitors reduce DUX4 and downstream gene expression and treat FSHD | 弗尔康医疗公司 | 2024-08-23 | — | — | CN | disclosed |
| CN-114748622-A | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD | 弗尔康医疗公司 | 2022-07-15 | — | — | CN | disclosed |
| CN-114732910-A | P38 kinase inhibitor reduces DUX4 and downstream gene expression for treatment of FSHD | 弗尔康医疗公司 | 2022-07-12 | — | — | CN | disclosed |
| CN-111601593-B | P38 kinase inhibitor reduces DUX4 and downstream gene expression for treatment of FSHD | 弗尔康医疗公司 | 2022-04-15 | — | — | CN | disclosed |