Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 20/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28899058 | 1.00 | MAPK14 (0.59) | MAPK14 | |
| SCHEMBL6472008 | 0.91 | MAPK14 (0.66) | MAPK14 | |
| SCHEMBL6503302 | 0.90 | MAPK14 (0.57) | MAPK14 | |
| SCHEMBL4387510 | 0.87 | MAPK14 (0.67) | MAPK14 | |
| SCHEMBL4376308 | 0.86 | MAPK14 (0.75) | MAPK14 | |
| SCHEMBL6501122 | 0.85 | MAPK14 (0.65) | MAPK14 | |
| SCHEMBL4375892 | 0.85 | MAPK14 (0.69) | MAPK14 | |
| SCHEMBL6502768 | 0.85 | MAPK14 (0.64) | MAPK14 | |
| SCHEMBL4379463 | 0.84 | MAPK14 (0.68) | MAPK14 | |
| SCHEMBL4376131 | 0.84 | MAPK14 (0.63) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114748622-A | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD | 弗尔康医疗公司 | 2022-07-15 | — | — | CN | disclosed |
| CN-114732910-A | P38 kinase inhibitor reduces DUX4 and downstream gene expression for treatment of FSHD | 弗尔康医疗公司 | 2022-07-12 | — | — | CN | disclosed |
| CN-111601593-B | P38 kinase inhibitor reduces DUX4 and downstream gene expression for treatment of FSHD | 弗尔康医疗公司 | 2022-04-15 | — | — | CN | disclosed |