Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 5/20 | 0.70 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.70 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PLAT | P00750 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4240627 | 1.00 | MAPK13 (0.70) | MAPK13MAPK11CYP2C9FGFR1FGFR2 | |
| SCHEMBL13928965 | 1.00 | MAPK13 (0.70) | MAPK13MAPK11CYP2C9FGFR1FGFR2 | |
| SCHEMBL4245583 | 0.91 | MAPK11 (0.77) | MAPK13MAPK11CYP2C9FGFR1FGFR2 | |
| SCHEMBL4760829 | 0.91 | MAPK11 (0.77) | MAPK13MAPK11CYP2C9FGFR1FGFR2 | |
| SCHEMBL4242581 | 0.84 | MAPK13 (0.54) | MAPK13MAPK11CYP2C9FGFR1FGFR2 | |
| SCHEMBL4240657 | 0.84 | MAPK13 (0.54) | MAPK13MAPK11CYP2C9FGFR1FGFR2 | |
| SCHEMBL4242576 | 0.83 | MAPK13 (0.69) | MAPK13MAPK11CYP2C9FGFR1FGFR2 | |
| As1940477 SCHEMBL4237689 | 0.82 | MAPK13 (1.00) | MAPK13MAPK11CYP2C9FGFR1FGFR2 | |
| As1940477 SCHEMBL20873909 | 0.82 | MAPK13 (1.00) | MAPK13MAPK11CYP2C9FGFR1FGFR2 | |
| As1940477 SCHEMBL29370514 | 0.82 | MAPK13 (1.00) | MAPK13MAPK11CYP2C9FGFR1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114748622-B | P38 kinase inhibitors reduce DUX4 and downstream gene expression and treat FSHD | 弗尔康医疗公司 | 2024-09-24 | — | — | CN | disclosed |
| CN-114732910-B | P38 kinase inhibitors reduce DUX4 and downstream gene expression and treat FSHD | 弗尔康医疗公司 | 2024-08-23 | — | — | CN | disclosed |
| CN-114748622-A | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD | 弗尔康医疗公司 | 2022-07-15 | — | — | CN | disclosed |
| CN-114732910-A | P38 kinase inhibitor reduces DUX4 and downstream gene expression for treatment of FSHD | 弗尔康医疗公司 | 2022-07-12 | — | — | CN | disclosed |
| CN-111601593-B | P38 kinase inhibitor reduces DUX4 and downstream gene expression for treatment of FSHD | 弗尔康医疗公司 | 2022-04-15 | — | — | CN | disclosed |