Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 5/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.60 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.60 |
| ▸ | ABL1 | P00519 | 3/20 | 0.60 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.60 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.60 |
| ▸ | EGFR | P00533 | 3/20 | 0.60 |
| ▸ | KIT | P10721 | 2/20 | 0.60 |
| ▸ | WEE1 | P30291 | 5/20 | 0.53 |
| ▸ | PLK2 | Q9NYY3 | 3/20 | 0.52 |
| ▸ | CDK4 | P11802 | 1/20 | 0.52 |
| ▸ | CCND1 | P24385 | 1/20 | 0.52 |
| ▸ | CCND2 | P30279 | 1/20 | 0.52 |
| ▸ | CCND3 | P30281 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
| ▸ | PLK1 | P53350 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5116444 | 1.00 | SRC (0.60) | SRCFGFR1MAPK14ABL1PDGFRB | |
| SCHEMBL5114082 | 0.95 | WEE1 (0.60) | SRCFGFR1MAPK14ABL1PDGFRB | |
| SCHEMBL14014933 | 0.93 | SRC (0.61) | SRCFGFR1MAPK14ABL1PDGFRB | |
| SCHEMBL13553949 | 0.89 | FGFR1 (0.62) | SRCFGFR1MAPK14ABL1PDGFRB | |
| SCHEMBL13553963 | 0.88 | PLK2 (0.56) | SRCFGFR1MAPK14ABL1PDGFRB | |
| SCHEMBL13553977 | 0.88 | PLK2 (0.61) | SRCFGFR1MAPK14ABL1PDGFRB | |
| SCHEMBL13553960 | 0.88 | PLK2 (0.71) | SRCFGFR1MAPK14ABL1PDGFRB | |
| SCHEMBL13553962 | 0.87 | PLK2 (0.56) | SRCFGFR1MAPK14ABL1PDGFRB | |
| SCHEMBL14014925 | 0.87 | WEE1 (0.66) | SRCFGFR1MAPK14ABL1PDGFRB | |
| SCHEMBL5109835 | 0.84 | FGFR1 (0.58) | SRCFGFR1MAPK14ABL1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114748622-B | P38 kinase inhibitors reduce DUX4 and downstream gene expression and treat FSHD | 弗尔康医疗公司 | 2024-09-24 | — | — | CN | disclosed |
| CN-114732910-B | P38 kinase inhibitors reduce DUX4 and downstream gene expression and treat FSHD | 弗尔康医疗公司 | 2024-08-23 | — | — | CN | disclosed |
| CN-114748622-A | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD | 弗尔康医疗公司 | 2022-07-15 | — | — | CN | disclosed |
| CN-114732910-A | P38 kinase inhibitor reduces DUX4 and downstream gene expression for treatment of FSHD | 弗尔康医疗公司 | 2022-07-12 | — | — | CN | disclosed |
| CN-111601593-B | P38 kinase inhibitor reduces DUX4 and downstream gene expression for treatment of FSHD | 弗尔康医疗公司 | 2022-04-15 | — | — | CN | disclosed |