SCHEMBL2959419

SCHEMBL2959419

c1ccc(OCCCCn2nncc2-c2ccc(N(c3ccc(-c4cnnn4CCCCOc4ccccc4)cc3)c3ccc(-c4cnnn4CCCCOc4ccccc4)cc3)cc2)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 1/20 0.46
KCNA3 P22001 1/20 0.40
HRH3 Q9Y5N1 4/20 0.39
TSHR P16473 2/20 0.39
LMNA P02545 1/20 0.39
ALOX15 P16050 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
KCNH2 Q12809 1/20 0.38
HRH4 Q9H3N8 1/20 0.38
USP2 O75604 2/20 0.37
ALDH1A1 P00352 1/20 0.37
CYP19A1 P11511 2/20 0.36
CYP1A2 P05177 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2D6 P10635 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
NPC1 O15118 1/20 0.36
MITF O75030 1/20 0.36
PKM P14618 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2953517 0.99 HDAC1 (0.48) HDAC1KCNA3HRH3KCNH2HRH4
SCHEMBL2955134 0.72 MEN1 (0.52) HDAC1
SCHEMBL25402344 0.72 HDAC1 (0.57) HDAC1TSHRCYP1A2CYP2C9CYP2C19
SCHEMBL2967024 0.72 MEN1 (0.51) HDAC1
SCHEMBL2899293 0.69 HDAC1 (0.60) HDAC1TSHRSMN1; SMN2CYP1A2CYP3A4
SCHEMBL8944007 0.69 KCNA3 (0.62) HDAC1KCNA3ALDH1A1CYP1A2CYP3A4
SCHEMBL5315811 0.69 HDAC1 (0.52) HDAC1TSHRALDH1A1CYP19A1CYP1A2
SCHEMBL8944087 0.68 KCNA3 (0.60) HDAC1KCNA3TSHRALDH1A1CYP1A2
SCHEMBL8944286 0.68 KCNA3 (0.60) HDAC1KCNA3TSHRALDH1A1CYP1A2
SCHEMBL8943680 0.68 KCNA3 (0.60) HDAC1KCNA3TSHRALDH1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7772358-B2 Polytriazoles constructed by 1,3-dipolar cycloaddition THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) 2010-08-10 US disclosed
US-20080103273-A1 Polytriazoles constructed by 1, 3-dipolar cycloaddition THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) 2008-05-01 US disclosed