Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK11 | Q15759 | 9/20 | 0.67 |
| ▸ | MAPK13 | O15264 | 8/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.67 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.49 |
| ▸ | MAPK12 | P53778 | 7/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13928940 | 1.00 | MAPK11 (0.67) | MAPK11MAPK13CYP2C9MAPK14MAPK12 | |
| SCHEMBL4236615 | 1.00 | MAPK11 (0.67) | MAPK11MAPK13CYP2C9MAPK14MAPK12 | |
| SCHEMBL29594441 | 0.94 | MAPK11 (0.67) | MAPK11MAPK13CYP2C9MAPK14MAPK12 | |
| SCHEMBL4236748 | 0.94 | MAPK11 (0.67) | MAPK11MAPK13CYP2C9MAPK14MAPK12 | |
| SCHEMBL4237696 | 0.93 | MAPK11 (0.66) | MAPK11MAPK13CYP2C9MAPK14MAPK12 | |
| SCHEMBL29593298 | 0.93 | MAPK11 (0.66) | MAPK11MAPK13CYP2C9MAPK14MAPK12 | |
| SCHEMBL4712606 | 0.93 | MAPK11 (0.66) | MAPK11MAPK13CYP2C9MAPK14MAPK12 | |
| SCHEMBL29593890 | 0.93 | MAPK11 (0.65) | MAPK11MAPK13CYP2C9MAPK14MAPK12 | |
| SCHEMBL4241029 | 0.93 | MAPK11 (0.65) | MAPK11MAPK13CYP2C9MAPK14MAPK12 | |
| SCHEMBL4246001 | 0.91 | MAPK11 (0.69) | MAPK11MAPK13CYP2C9MAPK14MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114748622-B | P38 kinase inhibitors reduce DUX4 and downstream gene expression and treat FSHD | 弗尔康医疗公司 | 2024-09-24 | — | — | CN | disclosed |
| CN-114732910-B | P38 kinase inhibitors reduce DUX4 and downstream gene expression and treat FSHD | 弗尔康医疗公司 | 2024-08-23 | — | — | CN | disclosed |
| CN-114748622-A | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD | 弗尔康医疗公司 | 2022-07-15 | — | — | CN | disclosed |
| CN-114732910-A | P38 kinase inhibitor reduces DUX4 and downstream gene expression for treatment of FSHD | 弗尔康医疗公司 | 2022-07-12 | — | — | CN | disclosed |
| CN-111601593-B | P38 kinase inhibitor reduces DUX4 and downstream gene expression for treatment of FSHD | 弗尔康医疗公司 | 2022-04-15 | — | — | CN | disclosed |