Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 5/20 | 0.53 |
| ▸ | DCK | P27707 | 2/20 | 0.48 |
| ▸ | GPR6 | P46095 | 2/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.46 |
| ▸ | HRH1 | P35367 | 3/20 | 0.43 |
| ▸ | CCR3 | P51677 | 3/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20298444 | 1.00 | CHRM4 (0.53) | CHRM4DCKGPR6LRRK2HRH1 | |
| SCHEMBL29596084 | 0.86 | CHRM4 (0.55) | CHRM4DCKGPR6LRRK2HRH1 | |
| SCHEMBL20302706 | 0.86 | CHRM4 (0.55) | CHRM4DCKGPR6LRRK2HRH1 | |
| SCHEMBL20298457 | 0.84 | CHRM4 (0.53) | CHRM4DCKGPR6LRRK2HRH1 | |
| SCHEMBL29595610 | 0.81 | CHRM4 (0.50) | CHRM4DCKGPR6LRRK2HRH1 | |
| SCHEMBL20298438 | 0.81 | CHRM4 (0.50) | CHRM4DCKGPR6LRRK2HRH1 | |
| SCHEMBL29594392 | 0.79 | CHRM4 (0.49) | CHRM4DCKGPR6LRRK2HRH1 | |
| SCHEMBL20302666 | 0.79 | GPR6 (0.51) | CHRM4DCKGPR6LRRK2HRH1 | |
| SCHEMBL20298516 | 0.79 | CHRM4 (0.51) | CHRM4DCKGPR6LRRK2HRH1 | |
| SCHEMBL29594463 | 0.79 | GPR6 (0.51) | CHRM4DCKGPR6LRRK2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11319298-B2 | Heteroaryl piperidine ether allosteric modulators of the M4 muscarinic acetylcholine receptor | MERCK SHARP & DOHME CORP. (US) | 2022-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11319298-B2 | Heteroaryl piperidine ether allosteric modulators of the M4 muscarinic acetylcholine receptor | CHRM4, CHRM2, CHRM5 | CHRM4 1/4885DCK 2633/4885GPR6 142/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.