Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | PIM2 | Q9P1W9 | 16/20 | 0.44 |
| ▸ | PIM1 | P11309 | 15/20 | 0.42 |
| ▸ | PIM3 | Q86V86 | 15/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15872828 | 1.00 | MAPT (0.47) | MAPTPIM2PIM1PIM3CYP1A2 | |
| SCHEMBL319232 | 0.85 | PIM1 (0.44) | MAPTPIM2PIM1PIM3CYP1A2 | |
| SCHEMBL320424 | 0.85 | PIM1 (0.43) | MAPTPIM2PIM1PIM3CYP1A2 | |
| SCHEMBL18652605 | 0.84 | MAPT (0.43) | MAPTCYP1A2GAARECQLNPC1 | |
| SCHEMBL319311 | 0.84 | PIM1 (0.46) | MAPTPIM2PIM1PIM3CYP1A2 | |
| SCHEMBL1711596 | 0.84 | PIM1 (0.44) | MAPTPIM2PIM1PIM3 | |
| SCHEMBL29599827 | 0.82 | PIM2 (0.46) | MAPTPIM2PIM1PIM3 | |
| SCHEMBL320431 | 0.82 | MAPT (0.37) | MAPTPIM2PIM1PIM3 | |
| SCHEMBL15872950 | 0.82 | PIM2 (0.46) | MAPTPIM2PIM1PIM3 | |
| SCHEMBL15883642 | 0.82 | PIM2 (0.44) | PIM2PIM1PIM3GSK3BPRKCQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108715590-B | Thiazolecarboxamide and picolinamide compounds useful as PIM kinase inhibitors | 因赛特公司 | 2022-03-08 | — | — | CN | disclosed |