Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 3/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 5/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24323923 | 1.00 | PDGFRB (0.40) | PDGFRBPDGFRAACACBPTGS1PTGS2 | |
| SCHEMBL15918737 | 0.78 | PDGFRB (0.41) | PDGFRBPDGFRAACACBPTGS1PTGS2 | |
| SCHEMBL1391081 | 0.77 | PARP10 (0.44) | ACACBFFAR4PARP10 | |
| SCHEMBL29955130 | 0.76 | PDGFRB (0.35) | PDGFRBPDGFRAABL1POLBPARP10 | |
| SCHEMBL17796055 | 0.75 | ERN1 (0.35) | — | |
| SCHEMBL15918602 | 0.74 | PDGFRB (0.44) | PDGFRBPDGFRAACACBPTGS1PTGS2 | |
| SCHEMBL20000562 | 0.74 | PDGFRB (0.44) | PDGFRBPDGFRAACACBPTGS1PTGS2 | |
| SCHEMBL20000529 | 0.74 | PDGFRB (0.48) | PDGFRBPDGFRAACACBPTGS1PTGS2 | |
| SCHEMBL16741178 | 0.73 | KDM4E (0.35) | PDGFRBPDGFRADHODH | |
| SCHEMBL24323638 | 0.73 | PARP10 (0.40) | PDGFRBPDGFRAACACBABL1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225765-A2 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076622-A2 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |