Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 3/20 | 0.53 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.43 |
| ▸ | PDE9A | O76083 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 6/20 | 0.37 |
| ▸ | IKBKE | Q14164 | 3/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22589726 | 0.91 | CHEK1 (0.46) | CHEK1LRRK2 | |
| SCHEMBL22589727 | 0.91 | CHEK1 (0.46) | CHEK1LRRK2 | |
| SCHEMBL31003122 | 0.89 | HRH3 (0.42) | CHEK1HRH3CHRM4 | |
| SCHEMBL22583070 | 0.84 | CHEK1 (0.39) | CHEK1HRH3CHRM4 | |
| SCHEMBL2585740 | 0.84 | HRH3 (0.46) | CHEK1HRH3CHRM4 | |
| SCHEMBL2584697 | 0.84 | HRH3 (0.46) | CHEK1HRH3CHRM4 | |
| SCHEMBL21606953 | 0.81 | HRH1 (0.49) | CHEK1HRH3 | |
| SCHEMBL28668218 | 0.81 | HRH3 (0.55) | HRH3 | |
| SCHEMBL22138855 | 0.81 | HRH3 (0.55) | HRH3 | |
| SCHEMBL29633126 | 0.81 | HRH3 (0.55) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4232449-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | Celgene Corporation (US) | 2023-08-30 | — | — | EP | disclosed |
| WO-2022087326-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | CELGENE CORPORATION (US) | 2022-04-28 | — | — | WO | disclosed |