Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | STS | P08842 | 1/20 | 0.36 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24047701 | 0.87 | HSD17B10 (0.50) | HSD17B10SMN1; SMN2BTKHPGDRECQL | |
| SCHEMBL26430589 | 0.87 | HSD17B10 (0.50) | HSD17B10SMN1; SMN2BTKHPGDRECQL | |
| SCHEMBL1439128 | 0.87 | HSD17B10 (0.50) | HSD17B10SMN1; SMN2BTKHPGDRECQL | |
| SCHEMBL17730541 | 0.86 | HSD17B10 (0.49) | HSD17B10SMN1; SMN2BTKHPGDRECQL | |
| SCHEMBL29785811 | 0.85 | HSD17B10 (0.48) | HSD17B10SMN1; SMN2BTKHPGDRECQL | |
| SCHEMBL1630474 | 0.84 | HTT (0.43) | HSD17B10SMN1; SMN2HPGDCHRM2CHRM1 | |
| SCHEMBL1630475 | 0.84 | HTT (0.43) | HSD17B10SMN1; SMN2HPGDCHRM2CHRM1 | |
| SCHEMBL1398690 | 0.84 | HTT (0.43) | HSD17B10SMN1; SMN2HPGDCHRM2CHRM1 | |
| SCHEMBL10215607 | 0.83 | CHRM2 (0.39) | HSD17B10SMN1; SMN2HPGDCHRM2CHRM1 | |
| SCHEMBL297706 | 0.83 | CHRM2 (0.39) | HSD17B10SMN1; SMN2HPGDCHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4056562-A1 | HETEROCYCLIC INHIBITORS OF BRUTON'S TYROSINE KINASE | Merck Patent GmbH (DE) | 2022-09-14 | — | — | EP | disclosed |
| EP-2718270-B1 | COMPOSITIONS AND METHODS FOR THE PRODUCTION OF PYRIMIDINE AND PYRIDINE COMPOUNDS WITH BTK INHIBITORY ACTIVITY | MERCK PATENT GMBH (DE) | 2022-04-27 | — | — | EP | disclosed |