Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.48 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.43 |
| ▸ | WNT3A | P56704 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15993270 | 1.00 | GSK3B (0.66) | GSK3BALDH1A1CES2CES1L3MBTL1 | |
| SCHEMBL6197746 | 0.84 | GSK3B (0.62) | GSK3BALDH1A1CES2CES1L3MBTL1 | |
| SCHEMBL19782864 | 0.83 | GSK3B (0.57) | GSK3BALDH1A1CES2CES1L3MBTL1 | |
| SCHEMBL15993216 | 0.83 | GSK3B (0.57) | GSK3BALDH1A1CES2CES1L3MBTL1 | |
| SCHEMBL19333994 | 0.82 | GSK3B (0.59) | GSK3BALDH1A1CES2CES1L3MBTL1 | |
| SCHEMBL15993028 | 0.82 | GSK3B (0.55) | GSK3BALDH1A1CES2CES1L3MBTL1 | |
| SCHEMBL19578168 | 0.81 | GSK3B (0.58) | GSK3BALDH1A1CES2CES1L3MBTL1 | |
| SCHEMBL7277861 | 0.81 | GSK3B (0.58) | GSK3BALDH1A1CES2CES1L3MBTL1 | |
| SCHEMBL19782876 | 0.81 | GSK3B (0.54) | GSK3BALDH1A1CES2CES1L3MBTL1 | |
| SCHEMBL5312170 | 0.80 | GSK3B (0.72) | GSK3BALDH1A1CES2CES1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4232449-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | Celgene Corporation (US) | 2023-08-30 | — | — | EP | disclosed |
| CN-116547282-A | Heterocyclic compounds and their use for the treatment of helminth infections and diseases | 新基公司 | 2023-08-04 | — | — | CN | disclosed |
| WO-2022087326-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | CELGENE CORPORATION (US) | 2022-04-28 | — | — | WO | disclosed |