Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 16/20 | 0.62 |
| ▸ | MARK3 | P27448 | 3/20 | 0.54 |
| ▸ | GSK3B | P49841 | 3/20 | 0.54 |
| ▸ | CAMK2B | Q13554 | 3/20 | 0.54 |
| ▸ | MARK2 | Q7KZI7 | 3/20 | 0.54 |
| ▸ | MINK1 | Q8N4C8 | 3/20 | 0.54 |
| ▸ | SRPK1 | Q96SB4 | 3/20 | 0.54 |
| ▸ | HIPK2 | Q9H2X6 | 3/20 | 0.54 |
| ▸ | CDC7 | O00311 | 2/20 | 0.54 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.54 |
| ▸ | NEK4 | P51957 | 2/20 | 0.54 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.54 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.54 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.54 |
| ▸ | HIPK4 | Q8NE63 | 2/20 | 0.54 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.54 |
| ▸ | EEF2K | O00418 | 1/20 | 0.54 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.54 |
| ▸ | PAK4 | O96013 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2205446 | 0.85 | MCL1 (0.72) | MCL1MARK3GSK3BCAMK2BMARK2 | |
| SCHEMBL29602354 | 0.84 | MCL1 (0.63) | MCL1MARK3GSK3BCAMK2BMARK2 | |
| SCHEMBL19615375 | 0.82 | MCL1 (0.51) | MCL1MARK3GSK3BCAMK2BMARK2 | |
| SCHEMBL28645820 | 0.81 | MCL1 (0.58) | MCL1MARK3CAMK2BMARK2HIPK2 | |
| SCHEMBL28926855 | 0.81 | MCL1 (0.59) | MCL1MARK3CAMK2BMARK2HIPK2 | |
| SCHEMBL28643047 | 0.81 | MCL1 (0.50) | MCL1MARK3GSK3BCAMK2BMARK2 | |
| SCHEMBL28652809 | 0.81 | MCL1 (0.58) | MCL1MARK3CAMK2BMARK2HIPK2 | |
| SCHEMBL19615964 | 0.80 | MCL1 (0.50) | MCL1ALBBCL2BCL2L1BAD | |
| SCHEMBL19615250 | 0.80 | MCL1 (0.50) | MCL1MARK3GSK3BCAMK2BMARK2 | |
| SCHEMBL19618985 | 0.80 | MCL1 (0.52) | MCL1MARK3GSK3BCAMK2BMARK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3458459-B1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER AG (DE) | 2022-04-27 | — | — | EP | disclosed |