Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.46 |
| ▸ | GRM5 | P41594 | 3/20 | 0.42 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.41 |
| ▸ | MIF | P14174 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 3/20 | 0.39 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.39 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29078774 | 1.00 | KDM4E (0.47) | KDM4EL3MBTL1GLAHTTKMT2A | |
| SCHEMBL31547061 | 0.89 | KDM4E (0.53) | KDM4EL3MBTL1GLAHTTKMT2A | |
| SCHEMBL10328687 | 0.89 | KDM4E (0.53) | KDM4EL3MBTL1GLAHTTKMT2A | |
| SCHEMBL10328691 | 0.86 | KDM4E (0.54) | KDM4EL3MBTL1GLAHTTKMT2A | |
| SCHEMBL14166822 | 0.86 | KDM4E (0.58) | KDM4EL3MBTL1GLAHTTKMT2A | |
| SCHEMBL29601311 | 0.85 | MAPK1 (0.48) | KDM4EL3MBTL1GRM5ACACBKAT2B | |
| SCHEMBL27039798 | 0.85 | GRM5 (0.42) | GRM5ACACBGRIN1GRIN2BHRH3 | |
| SCHEMBL29601242 | 0.82 | EGLN1 (0.47) | GRM5ACACBKAT2BCSF1RFLT3 | |
| SCHEMBL29078712 | 0.82 | EGLN1 (0.47) | GRM5ACACBKAT2BCSF1RFLT3 | |
| SCHEMBL12525671 | 0.80 | P4HTM (0.49) | KDM4EL3MBTL1GLAHTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4232449-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | Celgene Corporation (US) | 2023-08-30 | — | — | EP | disclosed |
| CN-116547282-A | Heterocyclic compounds and their use for the treatment of helminth infections and diseases | 新基公司 | 2023-08-04 | — | — | CN | disclosed |
| WO-2022087326-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | CELGENE CORPORATION (US) | 2022-04-28 | — | — | WO | disclosed |