Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 19/20 | 0.65 |
| ▸ | ALB | P02768 | 2/20 | 0.65 |
| ▸ | BCL2 | P10415 | 7/20 | 0.63 |
| ▸ | BCL2L1 | Q07817 | 7/20 | 0.63 |
| ▸ | BAD | Q92934 | 3/20 | 0.53 |
| ▸ | PMAIP1 | Q13794 | 4/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19615109 | 1.00 | MCL1 (0.65) | MCL1ALBBCL2BCL2L1BAD | |
| SCHEMBL19635604 | 0.92 | MCL1 (0.56) | MCL1ALBBCL2BCL2L1BAD | |
| SCHEMBL29602033 | 0.92 | MCL1 (0.56) | MCL1ALBBCL2BCL2L1BAD | |
| SCHEMBL19615275 | 0.85 | MCL1 (0.60) | MCL1ALBBCL2BCL2L1BAD | |
| SCHEMBL29602219 | 0.85 | MCL1 (0.60) | MCL1ALBBCL2BCL2L1BAD | |
| SCHEMBL23251273 | 0.83 | MCL1 (0.51) | MCL1ALBBCL2BCL2L1BAD | |
| SCHEMBL29602000 | 0.80 | MCL1 (0.48) | MCL1ALBBCL2BCL2L1PMAIP1 | |
| SCHEMBL4170698 | 0.79 | MCL1 (1.00) | MCL1ALBBCL2BCL2L1PMAIP1 | |
| SCHEMBL17686348 | 0.78 | MCL1 (1.00) | MCL1ALBBCL2BCL2L1BAD | |
| SCHEMBL19635474 | 0.78 | MCL1 (0.50) | MCL1ALBBCL2BCL2L1BAD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3458459-B1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER AG (DE) | 2022-04-27 | — | — | EP | claimed |
| EP-3458459-B1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER AG (DE) | 2022-04-27 | — | — | EP | disclosed |