Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 11/20 | 0.40 |
| ▸ | CXCR1 | P25024 | 3/20 | 0.39 |
| ▸ | NT5E | P21589 | 1/20 | 0.38 |
| ▸ | STK10 | O94804 | 1/20 | 0.36 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22616650 | 1.00 | CXCR2 (0.40) | CXCR2CXCR1NT5ESTK10SLK | |
| SCHEMBL29604489 | 0.88 | NT5E (0.43) | CXCR2CXCR1NT5ESTK10SLK | |
| SCHEMBL22616579 | 0.88 | NT5E (0.43) | CXCR2CXCR1NT5ESTK10SLK | |
| SCHEMBL22616456 | 0.85 | CXCR2 (0.45) | CXCR2CXCR1NT5ECYP2C9 | |
| SCHEMBL29604708 | 0.85 | CXCR2 (0.45) | CXCR2CXCR1NT5ECYP2C9 | |
| SCHEMBL22616454 | 0.84 | CXCR2 (0.44) | CXCR2CXCR1NT5EALDH1A1HPGD | |
| SCHEMBL29604443 | 0.84 | CXCR2 (0.44) | CXCR2CXCR1NT5EALDH1A1HPGD | |
| SCHEMBL22616453 | 0.82 | CXCR2 (0.43) | CXCR2CXCR1NT5ECYP2C9 | |
| SCHEMBL29604476 | 0.82 | CXCR2 (0.43) | CXCR2CXCR1NT5ECYP2C9 | |
| SCHEMBL22616552 | 0.81 | CXCR2 (0.47) | CXCR2CXCR1ALDH1A1SLC40A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114072393-B | 3-Amino-4H-benzo [ E ] [1,2,4] thiadiazine 1, 1-dioxide derivatives as MRGX2 inhibitors | 索伦特治疗有限责任公司 | 2025-05-27 | — | — | CN | disclosed |
| EP-3962901-A1 | 3-AMINO-4H-BENZO[E][1,2,4]THIADIAZINE 1,1-DIOXIDE DERIVATIVES AS INHIBITORS OF MRGX2 | Solent Therapeutics, LLC (US) | 2022-03-09 | — | — | EP | disclosed |