Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 5/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.34 |
| ▸ | PIM1 | P11309 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27134238 | 1.00 | MAP3K14 (0.39) | MAP3K14CYP19A1PIM1ALDH1A1MEN1 | |
| SCHEMBL26969483 | 1.00 | MAP3K14 (0.39) | MAP3K14CYP19A1PIM1ALDH1A1MEN1 | |
| SCHEMBL29605188 | 0.87 | CDK1 (0.45) | MAP3K14CDK1CCNB1GSK3B | |
| SCHEMBL26969451 | 0.87 | CDK1 (0.45) | MAP3K14CDK1CCNB1GSK3B | |
| SCHEMBL29605715 | 0.87 | CDK1 (0.45) | MAP3K14CDK1CCNB1GSK3B | |
| SCHEMBL29605063 | 0.85 | MAP3K14 (0.38) | MAP3K14CYP19A1PIM1ALDH1A1MEN1 | |
| SCHEMBL29604514 | 0.84 | MAP3K14 (0.38) | MAP3K14CYP19A1PIM1ALDH1A1MEN1 | |
| SCHEMBL29605856 | 0.84 | GSK3B (0.47) | CDK1CCNB1GSK3B | |
| SCHEMBL29604842 | 0.84 | GSK3B (0.47) | CDK1CCNB1GSK3B | |
| SCHEMBL29605411 | 0.84 | CYP19A1 (0.34) | CYP19A1PIM1ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4244224-A1 | SMALL MOLECULE INHIBITORS OF NF-KB INDUCING KINASE | JANSSEN Pharmaceutica NV (BE) | 2023-09-20 | — | — | EP | disclosed |
| WO-2022104348-A1 | SMALL MOLECULE INHIBITORS OF NF-KB INDUCING KINASE | JANSSEN PHARMACEUTICA NV (BE) | 2022-05-19 | — | — | WO | disclosed |