Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 6/20 | 0.41 |
| ▸ | FASN | P49327 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.39 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.38 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.38 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.37 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.37 |
| ▸ | CDC25A | P30304 | 1/20 | 0.36 |
| ▸ | CDC25B | P30305 | 1/20 | 0.36 |
| ▸ | CDC25C | P30307 | 1/20 | 0.36 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29605217 | 0.79 | MAP3K14 (0.50) | MAP3K14MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL29604666 | 0.79 | MAP3K14 (0.48) | MAP3K14ALDH1A1MAPTSMN1; SMN2RAB9A | |
| SCHEMBL29604858 | 0.78 | MAP3K14 (0.39) | MAP3K14SMN1; SMN2 | |
| SCHEMBL26643744 | 0.77 | MAP3K14 (0.40) | MAP3K14HSD17B1HSD17B2IDH1SREBF2 | |
| SCHEMBL26643945 | 0.77 | MAP3K14 (0.40) | MAP3K14HSD17B1HSD17B2SREBF2 | |
| SCHEMBL26643769 | 0.77 | MAP3K14 (0.40) | MAP3K14HSD17B1HSD17B2IDH1SREBF2 | |
| SCHEMBL31691126 | 0.77 | MAP3K14 (0.40) | MAP3K14HSD17B1HSD17B2IDH1SREBF2 | |
| SCHEMBL26643951 | 0.77 | MAP3K14 (0.40) | MAP3K14HSD17B1HSD17B2SREBF2 | |
| SCHEMBL29605327 | 0.77 | MAP3K14 (0.38) | MAP3K14HSD17B1HSD17B2IDH1SMN1; SMN2 | |
| SCHEMBL29605041 | 0.76 | MAP3K14 (0.36) | MAP3K14FASNBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4244224-A1 | SMALL MOLECULE INHIBITORS OF NF-KB INDUCING KINASE | JANSSEN Pharmaceutica NV (BE) | 2023-09-20 | — | — | EP | disclosed |
| WO-2022104348-A1 | SMALL MOLECULE INHIBITORS OF NF-KB INDUCING KINASE | JANSSEN PHARMACEUTICA NV (BE) | 2022-05-19 | — | — | WO | disclosed |