Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 19/20 | 0.66 |
| ▸ | TYK2 | P29597 | 14/20 | 0.66 |
| ▸ | FLT3 | P36888 | 8/20 | 0.66 |
| ▸ | JAK1 | P23458 | 7/20 | 0.66 |
| ▸ | JAK3 | P52333 | 6/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | LCK | P06239 | 1/20 | 0.66 |
| ▸ | LYN | P07948 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | CDK4 | P11802 | 1/20 | 0.66 |
| ▸ | FLT1 | P17948 | 1/20 | 0.66 |
| ▸ | CCND3 | P30281 | 1/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.66 |
| ▸ | FLT4 | P35916 | 1/20 | 0.66 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.66 |
| ▸ | WEE1 | P30291 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24663801 | 1.00 | JAK2 (0.66) | JAK2TYK2FLT3JAK1JAK3 | |
| SCHEMBL24664458 | 0.91 | CDK4 (0.61) | JAK2TYK2FLT3JAK1JAK3 | |
| SCHEMBL29608329 | 0.91 | CDK4 (0.61) | JAK2TYK2FLT3JAK1JAK3 | |
| SCHEMBL29608277 | 0.89 | JAK2 (0.82) | JAK2TYK2FLT3JAK1JAK3 | |
| SCHEMBL24664313 | 0.89 | JAK2 (0.82) | JAK2TYK2FLT3JAK1JAK3 | |
| SCHEMBL24664556 | 0.84 | JAK2 (0.80) | JAK2TYK2FLT3JAK1JAK3 | |
| SCHEMBL24664376 | 0.82 | CDK6 (0.72) | JAK2TYK2FLT3JAK1JAK3 | |
| SCHEMBL29527768 | 0.82 | CDK6 (0.72) | JAK2TYK2FLT3JAK1JAK3 | |
| SCHEMBL24664378 | 0.80 | JAK2 (0.82) | JAK2TYK2FLT3JAK1JAK3 | |
| SCHEMBL24664380 | 0.80 | JAK2 (0.92) | JAK2TYK2FLT3JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114423750-B | 2, 4-Disubstituted pyrimidine derivative, preparation method and application thereof | 成都赜灵生物医药科技有限公司 | 2024-04-19 | — | — | CN | disclosed |
| CN-114423750-A | 2, 4-disubstituted pyrimidine derivative and preparation method and application thereof | 成都赜灵生物医药科技有限公司 | 2022-04-29 | — | — | CN | disclosed |