Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 10/20 | 0.61 |
| ▸ | JAK2 | O60674 | 10/20 | 0.61 |
| ▸ | JAK1 | P23458 | 4/20 | 0.61 |
| ▸ | JAK3 | P52333 | 4/20 | 0.61 |
| ▸ | CDK4 | P11802 | 10/20 | 0.60 |
| ▸ | CDK6 | Q00534 | 10/20 | 0.60 |
| ▸ | TYK2 | P29597 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | LCK | P06239 | 1/20 | 0.60 |
| ▸ | LYN | P07948 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | FLT1 | P17948 | 1/20 | 0.60 |
| ▸ | CCND3 | P30281 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | FLT4 | P35916 | 1/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
| ▸ | CSF1R | P07333 | 9/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.53 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24664431 | 1.00 | FLT3 (0.61) | FLT3JAK2JAK1JAK3CDK4 | |
| SCHEMBL24664434 | 0.93 | JAK2 (0.71) | FLT3JAK2JAK1JAK3CDK4 | |
| SCHEMBL29607219 | 0.93 | JAK2 (0.71) | FLT3JAK2JAK1JAK3CDK4 | |
| SCHEMBL29608982 | 0.90 | CDK6 (0.67) | FLT3JAK2JAK1JAK3CDK4 | |
| SCHEMBL24664426 | 0.90 | CDK6 (0.67) | FLT3JAK2JAK1JAK3CDK4 | |
| SCHEMBL24664531 | 0.90 | CDK6 (0.62) | FLT3JAK2JAK1JAK3CDK4 | |
| SCHEMBL29607322 | 0.90 | CDK6 (0.62) | FLT3JAK2JAK1JAK3CDK4 | |
| SCHEMBL28773821 | 0.88 | CDK6 (0.58) | FLT3JAK2JAK1JAK3CDK4 | |
| SCHEMBL29608471 | 0.88 | CDK6 (0.58) | FLT3JAK2JAK1JAK3CDK4 | |
| SCHEMBL24663772 | 0.86 | CDK4 (0.53) | FLT3JAK2JAK1JAK3CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114423750-B | 2, 4-Disubstituted pyrimidine derivative, preparation method and application thereof | 成都赜灵生物医药科技有限公司 | 2024-04-19 | — | — | CN | disclosed |
| CN-114423750-A | 2, 4-disubstituted pyrimidine derivative and preparation method and application thereof | 成都赜灵生物医药科技有限公司 | 2022-04-29 | — | — | CN | disclosed |