Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK6 | Q00534 | 8/20 | 0.46 |
| ▸ | CDK1 | P06493 | 5/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.46 |
| ▸ | CDK2 | P24941 | 5/20 | 0.46 |
| ▸ | CCND3 | P30281 | 5/20 | 0.46 |
| ▸ | CCNE2 | O96020 | 4/20 | 0.46 |
| ▸ | CDK4 | P11802 | 5/20 | 0.46 |
| ▸ | CCND1 | P24385 | 3/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 4/20 | 0.45 |
| ▸ | TYK2 | P29597 | 4/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 2/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24663780 | 1.00 | CDK6 (0.46) | CDK6CDK1CCNA2CDK2CCND3 | |
| SCHEMBL24663787 | 0.93 | JAK2 (0.51) | CDK6CDK1CCNA2CDK2CCND3 | |
| SCHEMBL29607128 | 0.93 | JAK2 (0.51) | CDK6CDK1CCNA2CDK2CCND3 | |
| SCHEMBL24664385 | 0.86 | CDK6 (0.52) | CDK6CDK1CCNA2CDK2CCND3 | |
| SCHEMBL29608582 | 0.86 | CDK6 (0.52) | CDK6CDK1CCNA2CDK2CCND3 | |
| SCHEMBL24663772 | 0.84 | CDK4 (0.53) | CDK6CDK4JAK2TYK2CSF1R | |
| SCHEMBL29608267 | 0.84 | CDK4 (0.53) | CDK6CDK4JAK2TYK2CSF1R | |
| SCHEMBL30892011 | 0.79 | CDK6 (0.51) | CDK6CDK1CCNA2CDK2CCND3 | |
| SCHEMBL24663788 | 0.79 | CDK6 (0.51) | CDK6CDK1CCNA2CDK2CCND3 | |
| SCHEMBL24664306 | 0.78 | EGFR (0.55) | CDK6CDK1CCNA2CCND3CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114423750-B | 2, 4-Disubstituted pyrimidine derivative, preparation method and application thereof | 成都赜灵生物医药科技有限公司 | 2024-04-19 | — | — | CN | disclosed |
| CN-114423750-A | 2, 4-disubstituted pyrimidine derivative and preparation method and application thereof | 成都赜灵生物医药科技有限公司 | 2022-04-29 | — | — | CN | disclosed |