Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 11/20 | 0.67 |
| ▸ | CDK6 | Q00534 | 11/20 | 0.67 |
| ▸ | CSF1R | P07333 | 10/20 | 0.67 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.67 |
| ▸ | CCNK | O75909 | 2/20 | 0.59 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.59 |
| ▸ | CDK2 | P24941 | 2/20 | 0.59 |
| ▸ | CDK7 | P50613 | 2/20 | 0.59 |
| ▸ | CDK9 | P50750 | 2/20 | 0.59 |
| ▸ | CCNH | P51946 | 2/20 | 0.59 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.59 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.59 |
| ▸ | JAK2 | O60674 | 9/20 | 0.54 |
| ▸ | JAK1 | P23458 | 7/20 | 0.54 |
| ▸ | JAK3 | P52333 | 6/20 | 0.54 |
| ▸ | FLT3 | P36888 | 4/20 | 0.54 |
| ▸ | TYK2 | P29597 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | LYN | P07948 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24663782 | 1.00 | CDK4 (0.67) | CDK4CDK6CSF1RPIK3CDCCNK | |
| SCHEMBL24664301 | 0.90 | CDK4 (0.55) | CDK4CDK6CSF1RPIK3CDCCNK | |
| SCHEMBL24664302 | 0.89 | AXL (0.58) | CDK4CDK6CSF1RPIK3CDCCNA2 | |
| SCHEMBL29607708 | 0.89 | AXL (0.58) | CDK4CDK6CSF1RPIK3CDCCNA2 | |
| SCHEMBL24663799 | 0.87 | CDK4 (0.51) | CDK4CDK6CSF1RPIK3CDJAK2 | |
| SCHEMBL29607476 | 0.87 | CDK4 (0.51) | CDK4CDK6CSF1RPIK3CDJAK2 | |
| SCHEMBL24664376 | 0.86 | CDK6 (0.72) | CDK4CDK6CSF1RPIK3CDCCNK | |
| SCHEMBL29527768 | 0.86 | CDK6 (0.72) | CDK4CDK6CSF1RPIK3CDCCNK | |
| SCHEMBL21245569 | 0.80 | CSF1R (1.00) | CDK4CDK6CSF1RPIK3CDCCNK | |
| SCHEMBL24663778 | 0.80 | FLT3 (0.53) | CDK4CDK6CSF1RPIK3CDCCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114423750-B | 2, 4-Disubstituted pyrimidine derivative, preparation method and application thereof | 成都赜灵生物医药科技有限公司 | 2024-04-19 | — | — | CN | disclosed |
| CN-114423750-A | 2, 4-disubstituted pyrimidine derivative and preparation method and application thereof | 成都赜灵生物医药科技有限公司 | 2022-04-29 | — | — | CN | disclosed |