Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 13/20 | 0.60 |
| ▸ | JAK3 | P52333 | 13/20 | 0.60 |
| ▸ | JAK2 | O60674 | 11/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.60 |
| ▸ | TYK2 | P29597 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | STK16 | O75716 | 1/20 | 0.43 |
| ▸ | LATS1 | O95835 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | MST1R | Q04912 | 1/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.43 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.43 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.43 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL524757 | 1.00 | JAK1 (0.60) | JAK1JAK3JAK2CYP1A2TYK2 | |
| SCHEMBL525125 | 0.99 | JAK1 (0.59) | JAK1JAK3JAK2CYP1A2TYK2 | |
| SCHEMBL341026 | 0.99 | JAK1 (0.59) | JAK1JAK3JAK2CYP1A2TYK2 | |
| Calcium SCHEMBL29358619 | 0.99 | JAK1 (0.59) | JAK1JAK3JAK2CYP1A2TYK2 | |
| SCHEMBL346388 | 0.95 | JAK1 (0.52) | JAK1JAK3JAK2CYP1A2TYK2 | |
| SCHEMBL2990449 | 0.94 | JAK1 (0.61) | JAK1JAK3JAK2CYP1A2TYK2 | |
| SCHEMBL10177144 | 0.93 | JAK1 (0.60) | JAK1JAK3JAK2CYP1A2TYK2 | |
| SCHEMBL29358675 | 0.93 | JAK1 (0.60) | JAK1JAK3JAK2CYP1A2TYK2 | |
| SCHEMBL341025 | 0.93 | JAK1 (0.60) | JAK1JAK3JAK2CYP1A2TYK2 | |
| SCHEMBL12505135 | 0.92 | JAK1 (0.59) | JAK1JAK3JAK2CYP1A2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4009974-A1 | COMPOUNDS AND METHOD FOR TREATING CYTOKINE RELEASE SYNDROME | Rigel Pharmaceuticals, Inc. (US) | 2022-06-15 | — | — | EP | claimed |
| EP-4009974-A1 | COMPOUNDS AND METHOD FOR TREATING CYTOKINE RELEASE SYNDROME | Rigel Pharmaceuticals, Inc. (US) | 2022-06-15 | — | — | EP | disclosed |