Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | DHPS | P49366 | 2/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | CLK2 | P49760 | 3/20 | 0.37 |
| ▸ | CLK3 | P49761 | 3/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.37 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | WNT1 | P04628 | 2/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23390442 | 1.00 | GRM2 (0.37) | GRM2DHPSPDE4APDE4CPDE4D | |
| SCHEMBL26276312 | 1.00 | GRM2 (0.37) | GRM2DHPSPDE4APDE4CPDE4D | |
| SCHEMBL23390145 | 0.94 | PSD (0.40) | GRM2DHPSPDE4APDE4CPDE4D | |
| SCHEMBL30102064 | 0.94 | PIM1 (0.37) | GRM2DHPSPIM1ADORA2AADORA1 | |
| SCHEMBL26275469 | 0.94 | GRM2 (0.38) | GRM2DHPSPDE4APDE4CPDE4D | |
| SCHEMBL23951123 | 0.94 | PIM1 (0.37) | GRM2DHPSPIM1ADORA2AADORA1 | |
| SCHEMBL23390256 | 0.94 | PSD (0.40) | GRM2DHPSPDE4APDE4CPDE4D | |
| SCHEMBL23390147 | 0.94 | PSD (0.40) | GRM2DHPSPDE4APDE4CPDE4D | |
| SCHEMBL29611439 | 0.94 | PSD (0.40) | GRM2DHPSPDE4APDE4CPDE4D | |
| SCHEMBL26277141 | 0.94 | PSD (0.40) | GRM2DHPSPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4061484-A1 | PYRIDOPYRIMIDINONE DERIVATIVES AS AHR ANTAGONISTS | Senda Biosciences, Inc. (US) | 2022-09-28 | — | — | EP | claimed |
| EP-4228649-A1 | BIOMARKERS RELATED TO IMMUNE CHECKPOINT INHIBITOR THERAPY AND METHODS OF USING THE SAME | Senda Biosciences, Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| EP-4061484-A1 | PYRIDOPYRIMIDINONE DERIVATIVES AS AHR ANTAGONISTS | Senda Biosciences, Inc. (US) | 2022-09-28 | — | — | EP | disclosed |
| WO-2022081649-A1 | BIOMARKERS RELATED TO IMMUNE CHECKPOINT INHIBITOR THERAPY AND METHODS OF USING THE SAME | SENDA BIOSCIENCES, INC. (US) | 2022-04-21 | — | — | WO | disclosed |