SCHEMBL29610684

SCHEMBL29610684

Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1cnc(Cl)c(N2CCOCC2)c1

nearest known ligand 0.84

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
RAF1 P04049 19/20 0.84
BRAF P15056 11/20 0.84

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24312169 1.00 RAF1 (0.84) RAF1BRAF
SCHEMBL16121194 0.91 RAF1 (1.00) RAF1BRAF
SCHEMBL29566216 0.88 RAF1 (1.00) RAF1BRAF
SCHEMBL24312158 0.88 RAF1 (1.00) RAF1BRAF
SCHEMBL16035556 0.87 RAF1 (1.00) RAF1BRAF
SCHEMBL24312230 0.87 RAF1 (0.84) RAF1BRAF
SCHEMBL29566468 0.87 RAF1 (0.84) RAF1BRAF
SCHEMBL24312288 0.87 RAF1 (0.84) RAF1BRAF
SCHEMBL16121670 0.87 RAF1 (1.00) RAF1BRAF
SCHEMBL24312159 0.87 RAF1 (0.83) RAF1BRAF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022081469-A1 INHIBITORS OF RAF KINASES KINNATE BIOPHARMA INC. (US) 2022-04-21 WO disclosed