Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKZF2 | Q9UKS7 | 8/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 8/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 7/20 | 0.44 |
| ▸ | IKZF3 | Q9UKT9 | 5/20 | 0.44 |
| ▸ | TNF | P01375 | 4/20 | 0.44 |
| ▸ | IL1B | P01584 | 3/20 | 0.44 |
| ▸ | IKZF1 | Q13422 | 2/20 | 0.44 |
| ▸ | BCL2L11 | O43521 | 1/20 | 0.39 |
| ▸ | BCL2 | P10415 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24315907 | 1.00 | IKZF2 (0.46) | IKZF2CRBNDDB1IKZF3TNF | |
| SCHEMBL29611785 | 0.86 | IKZF2 (0.49) | IKZF2CRBNDDB1IKZF3IKZF1 | |
| SCHEMBL24315899 | 0.86 | IKZF2 (0.49) | IKZF2CRBNDDB1IKZF3IKZF1 | |
| SCHEMBL29610888 | 0.85 | IKZF2 (0.60) | IKZF2CRBNDDB1IKZF3IKZF1 | |
| SCHEMBL24315904 | 0.85 | IKZF2 (0.60) | IKZF2CRBNDDB1IKZF3IKZF1 | |
| SCHEMBL24316071 | 0.83 | IKZF2 (0.46) | IKZF2CRBNDDB1IKZF3TNF | |
| SCHEMBL29610440 | 0.82 | IKZF1 (0.47) | IKZF2CRBNDDB1IKZF3TNF | |
| SCHEMBL24315897 | 0.82 | IKZF1 (0.47) | IKZF2CRBNDDB1IKZF3TNF | |
| SCHEMBL24315890 | 0.81 | IKZF2 (0.55) | IKZF2CRBNDDB1IKZF3TNF | |
| SCHEMBL29611545 | 0.81 | IKZF2 (0.55) | IKZF2CRBNDDB1IKZF3TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4228639-A1 | TRICYCLIC LIGANDS FOR DEGRADATION OF IKZF2 OR IKZF4 | C4 Therapeutics, Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022081925-A1 | TRICYCLIC LIGANDS FOR DEGRADATION OF IKZF2 OR IKZF4 | C4 THERAPEUTICS, INC. (US) | 2022-04-21 | — | — | WO | disclosed |