Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 5/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 2/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23390088 | 1.00 | CYP1A2 (0.37) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL23390090 | 1.00 | CYP1A2 (0.37) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL26276209 | 0.88 | KDM5B (0.38) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL23390466 | 0.86 | AHR (0.42) | CYP1A2CYP3A4AHRPDE4APDE4C | |
| SCHEMBL29611147 | 0.86 | AHR (0.42) | CYP1A2CYP3A4AHRPDE4APDE4C | |
| SCHEMBL23390464 | 0.86 | AHR (0.42) | CYP1A2CYP3A4AHRPDE4APDE4C | |
| SCHEMBL23390222 | 0.86 | PSD (0.41) | CYP1A2CYP3A4CYP2C9CYP2C19PDE4A | |
| SCHEMBL23390224 | 0.86 | PSD (0.41) | CYP1A2CYP3A4CYP2C9CYP2C19PDE4A | |
| SCHEMBL23390278 | 0.86 | PSD (0.41) | CYP1A2CYP3A4CYP2C9CYP2C19PDE4A | |
| SCHEMBL23390388 | 0.85 | AHR (0.41) | CYP1A2CYP3A4AHRPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115397512-B | As AHR antagonists Pyridopyrimidinone derivatives | 先达生物科技公司 | 2024-12-17 | — | — | CN | claimed |
| CN-115397512-A | Pyridopyrimidinone derivatives as AHR antagonists | 先达生物科技公司 | 2022-11-25 | — | — | CN | claimed |
| EP-4061484-A1 | PYRIDOPYRIMIDINONE DERIVATIVES AS AHR ANTAGONISTS | Senda Biosciences, Inc. (US) | 2022-09-28 | — | — | EP | claimed |
| CN-115397512-B | As AHR antagonists Pyridopyrimidinone derivatives | 先达生物科技公司 | 2024-12-17 | — | — | CN | disclosed |
| CN-116745622-A | Biomarkers related to immune checkpoint inhibitor therapies and methods of use thereof | 先达生物科技公司 | 2023-09-12 | — | — | CN | disclosed |
| EP-4228649-A1 | BIOMARKERS RELATED TO IMMUNE CHECKPOINT INHIBITOR THERAPY AND METHODS OF USING THE SAME | Senda Biosciences, Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| CN-115397512-A | Pyridopyrimidinone derivatives as AHR antagonists | 先达生物科技公司 | 2022-11-25 | — | — | CN | disclosed |
| EP-4061484-A1 | PYRIDOPYRIMIDINONE DERIVATIVES AS AHR ANTAGONISTS | Senda Biosciences, Inc. (US) | 2022-09-28 | — | — | EP | disclosed |
| WO-2022081649-A1 | BIOMARKERS RELATED TO IMMUNE CHECKPOINT INHIBITOR THERAPY AND METHODS OF USING THE SAME | SENDA BIOSCIENCES, INC. (US) | 2022-04-21 | — | — | WO | disclosed |