Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 11/20 | 0.56 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.56 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.56 |
| ▸ | PI4KB | Q9UBF8 | 7/20 | 0.56 |
| ▸ | CLK2 | P49760 | 2/20 | 0.44 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | CLK1 | P49759 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | XIAP | P98170 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2952036 | 0.88 | PIK3CD (0.55) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL2321622 | 0.88 | PIK3CD (0.59) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL2957891 | 0.88 | PIK3CD (0.72) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL2325170 | 0.88 | PIK3CD (0.61) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL2360404 | 0.87 | PIK3CG (0.60) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL2328738 | 0.86 | PIK3CD (0.59) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL2320863 | 0.85 | PIK3CD (0.58) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL2948810 | 0.85 | PIK3CD (0.77) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL2361131 | 0.84 | PIK3CD (0.57) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL2331206 | 0.80 | PIK3CD (0.46) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7754746-B2 | Organic compounds | NOVARTIS AG (CH) | 2010-07-13 | — | — | US | claimed |
| US-20080319033-A1 | 3-{3-[5-(4-acetylphenyl)-4-methylthiazol-2-yl]-ureido}-N-tert-butylpropionamide, exhibiting phosphatidylinositol 3-kinase inhibitory activity and used for treating respiratory system disorders, such as asthma | NOVARTIS AG | 2008-12-25 | — | — | US | claimed |
| EP-1966175-A2 | ORGANIC COMPOUNDS | Novartis AG (CH) | 2008-09-10 | — | — | EP | claimed |
| WO-2007068473-A2 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2007-06-21 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080319033-A1 | 3-{3-[5-(4-acetylphenyl)-4-methylthiazol-2-yl]-ureido}-N-tert-butylpropionamide, exhibiting phosphatidylinositol 3-kinase inhibitory activity and used for treating respiratory system disorders, such as asthma | AKT3, PIK3R3, PIK3CD | PIK3CD 3/4885PIK3CG 10/4885PIK3CA 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.