Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.60 |
| ▸ | PKM | P14618 | 3/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | PDE5A | O76074 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.50 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.50 |
| ▸ | APEX1 | P27695 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | TOP2A | P11388 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.48 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22775824 | 1.00 | GAA (0.60) | GAAPKMTSHRPDE5ANPSR1 | |
| SCHEMBL23280146 | 0.89 | NPSR1 (0.50) | GAAPKMPDE5ANPSR1MAPT | |
| SCHEMBL6368877 | 0.89 | GAA (0.57) | GAAPKMTSHRMAPTKDM4E | |
| SCHEMBL20085778 | 0.89 | GAA (0.68) | GAAPKMTSHRPDE5ANPSR1 | |
| SCHEMBL6165371 | 0.89 | F2 (0.58) | GAATSHRNPSR1MAPTKDM4E | |
| SCHEMBL22775734 | 0.88 | PDE5A (0.56) | GAAPKMTSHRPDE5ANPSR1 | |
| SCHEMBL29431250 | 0.88 | PDE5A (0.56) | GAAPKMTSHRPDE5ANPSR1 | |
| SCHEMBL23280184 | 0.88 | NR4A2 (0.49) | GAAPKMTSHRPDE5ANPSR1 | |
| Guanidine SCHEMBL8688551 | 0.87 | F2 (0.52) | GAAPKMTSHRPDE5ANPSR1 | |
| SCHEMBL13991772 | 0.85 | SMN1; SMN2 (0.56) | GAAPKMTSHRMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4259607-A1 | BENZIMIDAZOLE DERIVATIVES FOR TREATING RESPIRATORY DISEASE | TMEM16A LIMITED (GB) | 2023-10-18 | — | — | EP | disclosed |
| WO-2022123314-A1 | BENZIMIDAZOLE DERIVATIVES FOR TREATING RESPIRATORY DISEASE | TMEM16A LIMITED (GB) | 2022-06-16 | — | — | WO | disclosed |
| EP-3983389-A1 | COMPOUNDS FOR TREATING RESPIRATORY DISEASE | TMEM16A LIMITED (GB) | 2022-04-20 | — | — | EP | disclosed |