Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TDO2 | P48775 | 1/20 | 0.42 |
| ▸ | NLRP3 | Q96P20 | 4/20 | 0.41 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.40 |
| ▸ | MPO | P05164 | 1/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.38 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17743393 | 1.00 | NOTUM (0.52) | NOTUMKDM4EALDH1A1MAPK1TDO2 | |
| SCHEMBL1953799 | 0.79 | NOTUM (0.47) | NOTUMKDM4EALDH1A1MAPK1TDO2 | |
| SCHEMBL18086479 | 0.78 | NOTUM (0.52) | NOTUMKDM4EALDH1A1MAPK1PCSK9 | |
| SCHEMBL30088437 | 0.78 | NOTUM (0.52) | NOTUMKDM4EALDH1A1MAPK1PCSK9 | |
| SCHEMBL27513112 | 0.78 | NOTUM (0.61) | NOTUMKDM4EALDH1A1MAPK1PCSK9 | |
| SCHEMBL23119642 | 0.78 | NOTUM (0.52) | NOTUMKDM4EALDH1A1MAPK1PCSK9 | |
| SCHEMBL23642208 | 0.78 | NOTUM (0.52) | NOTUMKDM4EALDH1A1MAPK1PCSK9 | |
| SCHEMBL31366246 | 0.78 | NOTUM (0.61) | NOTUMKDM4EALDH1A1MAPK1PCSK9 | |
| SCHEMBL23832369 | 0.77 | PCSK9 (0.48) | NOTUMKDM4EALDH1A1MAPK1NLRP3 | |
| SCHEMBL30088498 | 0.77 | PCSK9 (0.48) | NOTUMKDM4EALDH1A1MAPK1NLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109803963-B | Cyano-substituted heterocycles having USP30 inhibitor activity | 特殊治疗有限公司 | 2022-04-26 | — | — | CN | disclosed |