Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 18/20 | 1.00 |
| ▸ | CA12 | O43570 | 2/20 | 0.54 |
| ▸ | CA1 | P00915 | 2/20 | 0.54 |
| ▸ | CA2 | P00918 | 2/20 | 0.54 |
| ▸ | CA9 | Q16790 | 2/20 | 0.54 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.51 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23779565 | 1.00 | SCN10A (1.00) | SCN10ACA12CA1CA2CA9 | |
| SCHEMBL23779642 | 0.91 | SCN10A (0.83) | SCN10A | |
| SCHEMBL29615242 | 0.91 | SCN10A (0.83) | SCN10A | |
| SCHEMBL23779638 | 0.90 | SCN10A (0.82) | SCN10ACA12CA1CA2CA9 | |
| SCHEMBL23779443 | 0.89 | SCN10A (0.79) | SCN10ACA12CA1CA2CA9 | |
| SCHEMBL29615263 | 0.88 | SCN10A (0.78) | SCN10ACA12CA1CA2CA9 | |
| SCHEMBL23779504 | 0.88 | SCN10A (0.78) | SCN10ANR1I2CACNA1C | |
| SCHEMBL23779581 | 0.88 | SCN10A (0.78) | SCN10ACA12CA1CA2CA9 | |
| SCHEMBL23779529 | 0.87 | SCN10A (1.00) | SCN10ACA12CA1CA2CA9 | |
| SCHEMBL29615275 | 0.87 | SCN10A (1.00) | SCN10ACA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220119363-A1 | 2-AMINO-N-PHENYL-NICOTINAMIDES AS NAV1.8 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2022-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220119363-A1 | 2-AMINO-N-PHENYL-NICOTINAMIDES AS NAV1.8 INHIBITORS | SCN8A, TRPV1, SCN2A | SCN10A 8/4885CA12 3556/4885CA1 3007/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.