Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22462856 | 1.00 | NR1H2 (0.53) | NR1H2HPGDMAPTMEN1ALDH1A1 | |
| SCHEMBL21665989 | 1.00 | NR1H2 (0.53) | NR1H2HPGDMAPTMEN1ALDH1A1 | |
| SCHEMBL31434070 | 1.00 | NR1H2 (0.53) | NR1H2HPGDMAPTMEN1ALDH1A1 | |
| SCHEMBL34461164 | 1.00 | NR1H2 (0.53) | NR1H2HPGDMAPTMEN1ALDH1A1 | |
| SCHEMBL22462855 | 1.00 | NR1H2 (0.53) | NR1H2HPGDMAPTMEN1ALDH1A1 | |
| SCHEMBL25205542 | 0.90 | HPGD (0.48) | NR1H2HPGDMAPTMEN1ALDH1A1 | |
| SCHEMBL18309953 | 0.90 | HPGD (0.48) | NR1H2HPGDMAPTMEN1ALDH1A1 | |
| SCHEMBL14971268 | 0.90 | NR1H2 (0.53) | NR1H2HPGDMAPTMEN1ALDH1A1 | |
| SCHEMBL15076438 | 0.89 | NR1H2 (0.46) | NR1H2HPGDMAPTMEN1ALDH1A1 | |
| SCHEMBL15076681 | 0.89 | HPGD (0.47) | NR1H2HPGDMAPTMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4034538-A1 | NEW HETEROCYCLIC MONOACYLGLYCEROL LIPASE (MAGL) INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2022-08-03 | — | — | EP | disclosed |
| CN-114401968-A | Novel heterocyclic monoacylglycerol lipase (MAGL) inhibitors | 豪夫迈·罗氏有限公司 | 2022-04-26 | — | — | CN | disclosed |