Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK5 | Q8IW41 | 20/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 19/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 18/20 | 0.45 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24461392 | 1.00 | MAPKAPK5 (0.45) | MAPKAPK5MAPK14MAPK1MAPKAPK2 | |
| SCHEMBL25751371 | 0.94 | MAPKAPK5 (0.43) | MAPKAPK5MAPK14MAPK1MAPKAPK2 | |
| SCHEMBL24461637 | 0.92 | MAPKAPK5 (0.45) | MAPKAPK5MAPK14MAPK1MAPKAPK2 | |
| SCHEMBL29617114 | 0.92 | MAPKAPK5 (0.45) | MAPKAPK5MAPK14MAPK1MAPKAPK2 | |
| SCHEMBL24461685 | 0.92 | MAPKAPK5 (0.47) | MAPKAPK5MAPK14MAPK1MAPKAPK2 | |
| SCHEMBL25783440 | 0.91 | MAPKAPK5 (0.47) | MAPKAPK5MAPK14MAPK1MAPKAPK2 | |
| SCHEMBL24461761 | 0.91 | MAPKAPK5 (0.44) | MAPKAPK5MAPK14MAPK1MAPKAPK2 | |
| SCHEMBL30519920 | 0.91 | MAPKAPK5 (0.39) | MAPKAPK5MAPK14MAPK1MAPKAPK2 | |
| SCHEMBL24461563 | 0.91 | MAPKAPK5 (0.44) | MAPKAPK5MAPK14MAPK1MAPKAPK2 | |
| SCHEMBL30519879 | 0.90 | MAPKAPK5 (0.39) | MAPKAPK5MAPK14MAPK1MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119053588-A | P38 alpha-MK 2 inhibitor compound, pharmaceutical composition and application thereof | 长春金赛药业有限责任公司 | 2024-11-29 | — | — | CN | disclosed |
| EP-4247380-A1 | METHODS OF SYNTHESIZING SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | Aclaris Therapeutics, Inc. (US) | 2023-09-27 | — | — | EP | disclosed |
| CN-116685322-A | Method for synthesizing substituted pyridone-pyridyl compounds | 阿克拉瑞斯治疗股份有限公司 | 2023-09-01 | — | — | CN | disclosed |
| WO-2022109481-A1 | METHODS OF SYNTHESIZING SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | ACLARIS THERAPEUTICS, INC. (US) | 2022-05-27 | — | — | WO | disclosed |