Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK5 | Q8IW41 | 19/20 | 0.44 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 18/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 17/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24461597 | 1.00 | MAPKAPK5 (0.44) | MAPKAPK5MAPKAPK2MAPK14MAPK1MCHR1 | |
| SCHEMBL29617155 | 1.00 | MAPKAPK5 (0.44) | MAPKAPK5MAPKAPK2MAPK14MAPK1MCHR1 | |
| SCHEMBL29617156 | 1.00 | MAPKAPK5 (0.44) | MAPKAPK5MAPKAPK2MAPK14MAPK1MCHR1 | |
| SCHEMBL26328388 | 0.94 | MAPKAPK5 (0.42) | MAPKAPK5MAPKAPK2MAPK14MAPK1 | |
| SCHEMBL24461779 | 0.89 | MAPKAPK5 (0.43) | MAPKAPK5MAPKAPK2MAPK14MAPK1MCHR1 | |
| SCHEMBL24461765 | 0.87 | MAPKAPK5 (0.46) | MAPKAPK5MAPKAPK2MAPK14MAPK1MCHR1 | |
| SCHEMBL24461708 | 0.86 | MAPKAPK5 (0.43) | MAPKAPK5MAPKAPK2MAPK14MAPK1MCHR1 | |
| SCHEMBL29617160 | 0.86 | MAPKAPK5 (0.43) | MAPKAPK5MAPKAPK2MAPK14MAPK1MCHR1 | |
| SCHEMBL24461531 | 0.86 | MAPKAPK5 (0.43) | MAPKAPK5MAPKAPK2MAPK14MAPK1 | |
| SCHEMBL29617146 | 0.86 | MAPKAPK5 (0.43) | MAPKAPK5MAPKAPK2MAPK14MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4247380-A1 | METHODS OF SYNTHESIZING SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | Aclaris Therapeutics, Inc. (US) | 2023-09-27 | — | — | EP | disclosed |
| CN-116685322-A | Method for synthesizing substituted pyridone-pyridyl compounds | 阿克拉瑞斯治疗股份有限公司 | 2023-09-01 | — | — | CN | disclosed |
| WO-2022109481-A1 | METHODS OF SYNTHESIZING SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | ACLARIS THERAPEUTICS, INC. (US) | 2022-05-27 | — | — | WO | disclosed |