Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 20/20 | 0.82 |
| ▸ | JAK2 | O60674 | 19/20 | 0.82 |
| ▸ | TYK2 | P29597 | 17/20 | 0.82 |
| ▸ | CDK2 | P24941 | 14/20 | 0.82 |
| ▸ | CCNA2 | P20248 | 10/20 | 0.80 |
| ▸ | CCNA1 | P78396 | 10/20 | 0.80 |
| ▸ | JAK1 | P23458 | 13/20 | 0.77 |
| ▸ | JAK3 | P52333 | 5/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20322485 | 1.00 | FLT3 (0.82) | FLT3JAK2TYK2CDK2CCNA2 | |
| SCHEMBL1108225 | 0.91 | JAK2 (0.71) | FLT3JAK2TYK2CDK2CCNA2 | |
| SCHEMBL1108219 | 0.91 | JAK2 (0.71) | FLT3JAK2TYK2CDK2CCNA2 | |
| SCHEMBL1108269 | 0.90 | FLT3 (1.00) | FLT3JAK2TYK2CDK2CCNA2 | |
| SCHEMBL823902 | 0.90 | FLT3 (0.67) | FLT3JAK2TYK2CDK2CCNA2 | |
| SCHEMBL824044 | 0.89 | FLT3 (1.00) | FLT3JAK2TYK2CDK2CCNA2 | |
| SCHEMBL824054 | 0.89 | FLT3 (1.00) | FLT3JAK2TYK2CDK2CCNA2 | |
| SCHEMBL823837 | 0.89 | FLT3 (0.69) | FLT3JAK2TYK2CDK2CCNA2 | |
| SCHEMBL1108223 | 0.88 | JAK2 (0.78) | FLT3JAK2TYK2CDK2CCNA2 | |
| SCHEMBL20322488 | 0.87 | JAK2 (0.79) | FLT3JAK2TYK2CDK2CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3179992-B1 | THERAPEUTIC COMBINATIONS OF A BTK INHIBITOR, A PD-1 INHIBITOR AND/OR A PD-L1 INHIBITOR | ACERTA PHARMA BV (NL) | 2022-05-11 | — | — | EP | disclosed |