Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.59 |
| ▸ | BTK | Q06187 | 2/20 | 0.59 |
| ▸ | PI4KB | Q9UBF8 | 6/20 | 0.51 |
| ▸ | PI4KA | P42356 | 5/20 | 0.51 |
| ▸ | PI4K2B | Q8TCG2 | 5/20 | 0.51 |
| ▸ | PI4K2A | Q9BTU6 | 5/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.49 |
| ▸ | ABL1 | P00519 | 4/20 | 0.47 |
| ▸ | BCR | P11274 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.46 |
| ▸ | SLC2A2 | P11168 | 1/20 | 0.46 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.46 |
| ▸ | PAK4 | O96013 | 2/20 | 0.46 |
| ▸ | LCK | P06239 | 2/20 | 0.46 |
| ▸ | FYN | P06241 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19362509 | 1.00 | EGFR (0.59) | EGFRBTKPI4KBPI4KAPI4K2B | |
| SCHEMBL19463908 | 0.98 | EGFR (0.58) | EGFRBTKPI4KBPI4KAPI4K2B | |
| SCHEMBL31037237 | 0.98 | EGFR (0.58) | EGFRBTKPI4KBPI4KAPI4K2B | |
| SCHEMBL21807058 | 0.97 | EGFR (0.59) | EGFRBTKPI4KBPI4KAPI4K2B | |
| SCHEMBL20744975 | 0.93 | EGFR (0.55) | EGFRBTKPI4KBPI4KAPI4K2B | |
| SCHEMBL30041613 | 0.93 | EGFR (0.55) | EGFRBTKPI4KBPI4KAPI4K2B | |
| SCHEMBL1501671 | 0.86 | EGFR (0.50) | EGFRBTKPI4KBPI4KAPI4K2B | |
| SCHEMBL29886844 | 0.86 | EGFR (0.50) | EGFRBTKPI4KBPI4KAPI4K2B | |
| Hydrochloric Acid SCHEMBL1501585 | 0.85 | EGFR (0.49) | EGFRBTKPI4KBPI4KAPI4K2B | |
| SCHEMBL13762806 | 0.85 | PI4KA (0.54) | EGFRBTKPI4KBPI4KAPI4K2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114685516-A | Pyrazolopyrimidine derivatives as BTK inhibitors for the treatment of cancer | 洛克索肿瘤学股份有限公司 | 2022-07-01 | — | — | CN | disclosed |
| CN-108431007-B | Pyrazolopyrimidine derivatives as BTK inhibitors for the treatment of cancer | 洛克索肿瘤学股份有限公司 | 2022-06-07 | — | — | CN | disclosed |